Display options
Cite
Jung HS, Park CH, Park YT, et al. Gynecomastia induced by H1-antihistamine (ebastine) in a patient with idiopathic anaphylaxis. Asia Pac Allergy. 2015;5(3):187-90doi: 10.5415/apallergy.2015.5.3.187.
Jung, H. S., Park, C. H., Park, Y. T., Bae, M. A., Lee, Y. I., Kang, B. J., Jegal, Y., Ahn, J. J., & Lee, T. (2015). Gynecomastia induced by H1-antihistamine (ebastine) in a patient with idiopathic anaphylaxis. Asia Pacific allergy, 5(3), 187-90. https://doi.org/10.5415/apallergy.2015.5.3.187
Jung, Hwa Sik, et al. "Gynecomastia induced by H1-antihistamine (ebastine) in a patient with idiopathic anaphylaxis." Asia Pacific allergy vol. 5,3 (2015): 187-90. doi: https://doi.org/10.5415/apallergy.2015.5.3.187
Jung HS, Park CH, Park YT, Bae MA, Lee YI, Kang BJ, Jegal Y, Ahn JJ, Lee T. Gynecomastia induced by H1-antihistamine (ebastine) in a patient with idiopathic anaphylaxis. Asia Pac Allergy. 2015 Jul;5(3):187-90. doi: 10.5415/apallergy.2015.5.3.187. Epub 2015 Jul 29. PMID: 26240797; PMCID: PMC4521169.
Copy Download .nbib Format: NLM
Share it on

Asia Pac Allergy. 2015 Jul;5(3):187-90. doi: 10.5415/apallergy.2015.5.3.187. Epub 2015 Jul 29.

Gynecomastia induced by H1-antihistamine (ebastine) in a patient with idiopathic anaphylaxis.

Asia Pacific allergy

Hwa Sik Jung, Chan-Ho Park, Young Tae Park, Mi Ae Bae, Youn Im Lee, Byung Ju Kang, Yangjin Jegal, Jong Joon Ahn, Taehoon Lee

Affiliations

  1. Department of Internal Medicine, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan 682-714, Korea.

PMID: 26240797 PMCID: PMC4521169 DOI: 10.5415/apallergy.2015.5.3.187

Abstract

H1-antihistamine is generally a well-tolerated and safe drug. However, in resemblance with all other drugs, H1-antihistamines can also prompt adverse drug reactions (ADRs). We recently encountered the very unusual ADR of H1-antihistamine-induced gynecomastia. A 21-year-old man with idiopathic anaphylaxis was treated with ebastine (Ebastel), a second-generation H1-antihistamine, for the prevention of anaphylaxis. Three months later, the patient remained well without anaphylaxis, but had newly developed gynecomastia. Because anaphylaxis recurred after the cessation of H1-antihistamine, the preventive medication was changed to omalizumab. A few months later, his gynecomastia had entirely disappeared. Physicians should be aware of this exceptional ADR of H1-antihistamine.

Keywords: Anaphylaxis; Gynecomastia; Histamine H1 Antagonists

References

  1. Pharmacotherapy. 2012 Dec;32(12):1123-40 - PubMed
  2. Clin Exp Allergy. 1999 Jul;29 Suppl 3:77-81 - PubMed
  3. Int J Clin Pract. 2007 Jul;61(7):1209-15 - PubMed
  4. J Allergy Clin Immunol. 2011 Dec;128(6):1139-1150.e4 - PubMed
  5. N Engl J Med. 2004 Nov 18;351(21):2203-17 - PubMed
  6. N Engl J Med. 2007 Sep 20;357(12):1229-37 - PubMed
  7. Indian J Endocrinol Metab. 2014 Mar;18(2):150-8 - PubMed
  8. Therapie. 2004 Jan-Feb;59(1):163-4 - PubMed

Publication Types