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Agodi A, Barchitta M, Quattrocchi A, et al. Low fruit consumption and folate deficiency are associated with LINE-1 hypomethylation in women of a cancer-free population. Genes Nutr. 2015;10(5):480doi: 10.1007/s12263-015-0480-4.
Agodi, A., Barchitta, M., Quattrocchi, A., Maugeri, A., Canto, C., Marchese, A. E., & Vinciguerra, M. (2015). Low fruit consumption and folate deficiency are associated with LINE-1 hypomethylation in women of a cancer-free population. Genes & nutrition, 10(5), 480. https://doi.org/10.1007/s12263-015-0480-4
Agodi, Antonella, et al. "Low fruit consumption and folate deficiency are associated with LINE-1 hypomethylation in women of a cancer-free population." Genes & nutrition vol. 10,5 (2015): 480. doi: https://doi.org/10.1007/s12263-015-0480-4
Agodi A, Barchitta M, Quattrocchi A, Maugeri A, Canto C, Marchese AE, Vinciguerra M. Low fruit consumption and folate deficiency are associated with LINE-1 hypomethylation in women of a cancer-free population. Genes Nutr. 2015 Sep;10(5):480. doi: 10.1007/s12263-015-0480-4. Epub 2015 Jul 17. PMID: 26183162; PMCID: PMC4504850.
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Genes Nutr. 2015 Sep;10(5):480. doi: 10.1007/s12263-015-0480-4. Epub 2015 Jul 17.

Low fruit consumption and folate deficiency are associated with LINE-1 hypomethylation in women of a cancer-free population.

Genes & nutrition

Antonella Agodi, Martina Barchitta, Annalisa Quattrocchi, Andrea Maugeri, Carolina Canto, Anna Elisa Marchese, Manlio Vinciguerra

Affiliations

  1. Department of Medical and Surgical Sciences and Advanced Technologies "GF Ingrassia", University of Catania, Via S. Sofia 87, 95121, Catania, Italy, [email protected].

PMID: 26183162 PMCID: PMC4504850 DOI: 10.1007/s12263-015-0480-4

Abstract

Several dietary agents, such as micronutrient and non-nutrient components, the so-called bioactive food components, have been shown to display anticancer properties and influence genetic processes. The most common epigenetic change is DNA methylation. Hypomethylation of long interspersed elements (LINE-1) has been associated with an increased risk of several cancers, although conflicting findings have also been observed. The aim of the present study was to test the hypothesis that a low adherence to the Mediterranean diet (MD) and folate deficiency may cause LINE-1 hypomethylation in blood leukocytes of healthy women, and thus genomic instability. One hundred and seventy-seven non-pregnant women were enrolled. Mediterranean diet score (MDS) and folate intake were calculated using a food frequency questionnaire. LINE-1 methylation level was measured by pyrosequencing analysis in three CpG sites of LINE-1 promoter. According to MDS, only 9.6 % of subjects achieved a high adherence to MD. Taking into account the use of supplements, there was a high prevalence of folate deficiency (73.4 %). Women whose consumption of fruit was below the median value (i.e., <201 gr/day) were 3.7 times more likely to display LINE-1 hypomethylation than women whose consumption was above the median value (OR 3.7; 95 % CI 1.4-9.5). Similarly, women with folate deficiency were 3.6 times more likely to display LINE-1 hypomethylation than women with no folate deficiency (OR 3.6; 95 % CI 1.1-12.1). A dietary pattern characterized by low fruit consumption and folate deficiency is associated with LINE-1 hypomethylation and with cancer risk.

References

  1. Int J Epidemiol. 2012 Feb;41(1):126-39 - PubMed
  2. Mutagenesis. 2014 Mar;29(2):101-6 - PubMed
  3. Public Health Nutr. 2014 Mar;17(3):648-56 - PubMed
  4. Cancer Epidemiol Biomarkers Prev. 2009 May;18(5):1439-47 - PubMed
  5. Am J Clin Nutr. 2010 Nov;92(5):1189-96 - PubMed
  6. J Nutrigenet Nutrigenomics. 2011;4(5):275-92 - PubMed
  7. J Nutr. 2015 Apr;145(4):783-90 - PubMed
  8. Gynecol Oncol. 2009 Feb;112(2):293-9 - PubMed
  9. Int J Cancer. 2010 Oct 15;127(8):1866-74 - PubMed
  10. Clin Cancer Res. 2010 Mar 1;16(5):1682-9 - PubMed
  11. Carcinogenesis. 2014 Feb;35(2):333-8 - PubMed
  12. Lancet Oncol. 2008 Apr;9(4):359-66 - PubMed
  13. Epigenetics. 2014 Feb;9(2):243-8 - PubMed
  14. PLoS One. 2012;7(12):e52570 - PubMed
  15. J Nutr. 2004 Sep;134(9):2492S-2498S - PubMed
  16. Gut. 2005 May;54(5):648-53 - PubMed
  17. Br J Cancer. 2015 May 26;112(11):1816-21 - PubMed
  18. Epigenetics. 2011 Jan;6(1):29-33 - PubMed
  19. Front Genet. 2012 Jan 09;2:91 - PubMed
  20. Nucleic Acids Res. 2005 Dec 02;33(21):6823-36 - PubMed
  21. Cancer Epidemiol Biomarkers Prev. 2007 Jan;16(1):108-14 - PubMed
  22. Ann Nutr Metab. 2013;63(3):179-85 - PubMed
  23. Cancer Prev Res (Phila). 2012 Mar;5(3):385-92 - PubMed
  24. Adv Nutr. 2012 Jan;3(1):21-38 - PubMed
  25. Lancet Neurol. 2009 Nov;8(11):1056-72 - PubMed
  26. PLoS One. 2012;7(8):e43134 - PubMed
  27. PLoS One. 2007 May 02;2(5):e399 - PubMed
  28. Br J Cancer. 2011 Apr 26;104(9):1493-9 - PubMed
  29. J Periodontol. 2008 Aug;79(8 Suppl):1514-9 - PubMed
  30. Carcinogenesis. 2009 Nov;30(11):1889-97 - PubMed
  31. Am J Clin Nutr. 2006 May;83(5):993-1016 - PubMed
  32. World Health Organ Tech Rep Ser. 1995;854:1-452 - PubMed
  33. N Engl J Med. 2011 Jun 23;364(25):2392-404 - PubMed
  34. PLoS One. 2014 Oct 02;9(10):e109478 - PubMed
  35. Int J Cancer. 2013 Jun 15;132(12):2918-27 - PubMed
  36. PLoS One. 2012;7(4):e34615 - PubMed
  37. Gene. 2008 Aug 1;419(1-2):75-81 - PubMed
  38. Epigenomics. 2011 Aug;3(4):503-18 - PubMed
  39. J Nutr. 2011 Jun;141(6):1165-71 - PubMed
  40. Eur J Clin Nutr. 2011 Dec;65(12):1302-8 - PubMed
  41. Exp Biol Med (Maywood). 2004 Nov;229(10):988-95 - PubMed
  42. Epigenetics. 2011 Mar;6(3):293-9 - PubMed
  43. Mol Nutr Food Res. 2007 Mar;51(3):267-92 - PubMed
  44. BMJ. 1995 Dec 2;311(7018):1457-60 - PubMed
  45. Mol Nutr Food Res. 2014 Jul;58(7):1528-36 - PubMed
  46. Nutrition. 2011 May;27(5):513-9 - PubMed
  47. J Med Genet. 2003 Aug;40(8):619-25 - PubMed
  48. Nutrition. 2014 Jul-Aug;30(7-8):822-30 - PubMed
  49. J Am Diet Assoc. 2007 Jul;107(7):1233-9 - PubMed
  50. Science. 2004 Mar 12;303(5664):1626-32 - PubMed
  51. Public Health Nutr. 2009 Sep;12 (9A):1676-84 - PubMed
  52. Gastroenterology. 2008 Jan;134(1):47-55 - PubMed
  53. Biomed Res Int. 2014;2014:742620 - PubMed
  54. Epigenetics. 2012 Jun 1;7(6):606-14 - PubMed
  55. Eur J Nutr. 2013 Mar;52(2):677-85 - PubMed
  56. BMC Med Genomics. 2012 Jun 06;5:20 - PubMed
  57. Cancer Sci. 2012 Dec;103(12):2159-64 - PubMed
  58. J Inherit Metab Dis. 2011 Feb;34(1):101-9 - PubMed
  59. Proc Natl Acad Sci U S A. 2002 Apr 16;99(8):5606-11 - PubMed
  60. Br J Cancer. 2014 Sep 23;111(7):1454-62 - PubMed
  61. J Nutr. 1998 Jul;128(7):1204-12 - PubMed
  62. Nucleic Acids Res. 2004 Feb 18;32(3):e38 - PubMed

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