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Angelone T, Quintieri AM, Pasqua T, et al. The NO stimulator, Catestatin, improves the Frank-Starling response in normotensive and hypertensive rat hearts. Nitric Oxide. 2015;50:10-19doi: 10.1016/j.niox.2015.07.004.
Angelone, T., Quintieri, A. M., Pasqua, T., Filice, E., Cantafio, P., Scavello, F., Rocca, C., Mahata, S. K., Gattuso, A., & Cerra, M. C. (2015). The NO stimulator, Catestatin, improves the Frank-Starling response in normotensive and hypertensive rat hearts. Nitric oxide : biology and chemistry, 5010-19. https://doi.org/10.1016/j.niox.2015.07.004
Angelone, T, et al. "The NO stimulator, Catestatin, improves the Frank-Starling response in normotensive and hypertensive rat hearts." Nitric oxide : biology and chemistry vol. 50 (2015): 10-19. doi: https://doi.org/10.1016/j.niox.2015.07.004
Angelone T, Quintieri AM, Pasqua T, Filice E, Cantafio P, Scavello F, Rocca C, Mahata SK, Gattuso A, Cerra MC. The NO stimulator, Catestatin, improves the Frank-Starling response in normotensive and hypertensive rat hearts. Nitric Oxide. 2015 Nov 15;50:10-19. doi: 10.1016/j.niox.2015.07.004. Epub 2015 Aug 01. PMID: 26241941.
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Nitric Oxide. 2015 Nov 15;50:10-19. doi: 10.1016/j.niox.2015.07.004. Epub 2015 Aug 01.

The NO stimulator, Catestatin, improves the Frank-Starling response in normotensive and hypertensive rat hearts.

Nitric oxide : biology and chemistry

T Angelone, A M Quintieri, T Pasqua, E Filice, P Cantafio, F Scavello, C Rocca, S K Mahata, A Gattuso, M C Cerra

Affiliations

  1. Dept of Biology, Ecology and Earth Sciences, University of Calabria, Rende, CS, Italy; National Institute of Cardiovascular Research, Bologna, Italy.
  2. Dept of Biology, Ecology and Earth Sciences, University of Calabria, Rende, CS, Italy.
  3. Department of Medicine, University of California & VA San Diego Healthcare System, San Diego, USA.
  4. Dept of Biology, Ecology and Earth Sciences, University of Calabria, Rende, CS, Italy. Electronic address: [email protected].
  5. Dept of Biology, Ecology and Earth Sciences, University of Calabria, Rende, CS, Italy; National Institute of Cardiovascular Research, Bologna, Italy. Electronic address: [email protected].

PMID: 26241941 DOI: 10.1016/j.niox.2015.07.004

Abstract

The myocardial response to mechanical stretch (Frank-Starling law) is an important physiological cardiac determinant. Modulated by many endogenous substances, it is impaired in the presence of cardiovascular pathologies and during senescence. Catestatin (CST:hCgA352-372), a 21-amino-acid derivate of Chromogranin A (CgA), displays hypotensive/vasodilatory properties and counteracts excessive systemic and/or intra-cardiac excitatory stimuli (e.g., catecholamines and endothelin-1). CST, produced also by the myocardium, affects the heart by modulating inotropy, lusitropy and the coronary tone through a Nitric Oxide (NO)-dependent mechanism. This study evaluated the putative influence elicited by CST on the Frank-Starling response of normotensive Wistar-Kyoto (WKY) and hypertensive (SHR) hearts by using isolated and Langendorff perfused cardiac preparations. Functional changes were evaluated on aged (18-month-old) WKY rats and SHR which mimic human chronic heart failure (HF). Comparison to WKY rats, SHR showed a reduced Frank-Starling response. In both rat strains, CST administration improved myocardial mechanical response to increased end-diastolic pressures. This effect was mediated by EE/IP3K/NOS/NO/cGMP/PKG, as revealed by specific inhibitors. CST-dependent positive Frank-Starling response is paralleled by an increment in protein S-Nitrosylation. Our data suggested CST as a NO-dependent physiological modulator of the stretch-induced intrinsic regulation of the heart. This may be of particular importance in the aged hypertrophic heart, whose function is impaired because of a reduced systolic performance accompanied by delayed relaxation and increased diastolic stiffness.

Copyright © 2015 Elsevier Inc. All rights reserved.

Keywords: Catestatin; Chromogranins; Heart; Intracellular signaling; Nitric oxide

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