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Hennig S, Rödel G, Ostermann K. Artificial cell-cell communication as an emerging tool in synthetic biology applications. J Biol Eng. 2015;9:13doi: 10.1186/s13036-015-0011-2.
Hennig, S., Rödel, G., & Ostermann, K. (2015). Artificial cell-cell communication as an emerging tool in synthetic biology applications. Journal of biological engineering, 913. https://doi.org/10.1186/s13036-015-0011-2
Hennig, Stefan, et al. "Artificial cell-cell communication as an emerging tool in synthetic biology applications." Journal of biological engineering vol. 9 (2015): 13. doi: https://doi.org/10.1186/s13036-015-0011-2
Hennig S, Rödel G, Ostermann K. Artificial cell-cell communication as an emerging tool in synthetic biology applications. J Biol Eng. 2015 Aug 12;9:13. doi: 10.1186/s13036-015-0011-2. eCollection 2015. PMID: 26265937; PMCID: PMC4531478.
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J Biol Eng. 2015 Aug 12;9:13. doi: 10.1186/s13036-015-0011-2. eCollection 2015.

Artificial cell-cell communication as an emerging tool in synthetic biology applications.

Journal of biological engineering

Stefan Hennig, Gerhard Rödel, Kai Ostermann

Affiliations

  1. Institute of Genetics, Technische Universität Dresden, 01062 Dresden, Germany.

PMID: 26265937 PMCID: PMC4531478 DOI: 10.1186/s13036-015-0011-2

Abstract

Cell-cell communication is a widespread phenomenon in nature, ranging from bacterial quorum sensing and fungal pheromone communication to cellular crosstalk in multicellular eukaryotes. These communication modes offer the possibility to control the behavior of an entire community by modifying the performance of individual cells in specific ways. Synthetic biology, i.e., the implementation of artificial functions within biological systems, is a promising approach towards the engineering of sophisticated, autonomous devices based on specifically functionalized cells. With the growing complexity of the functions performed by such systems, both the risk of circuit crosstalk and the metabolic burden resulting from the expression of numerous foreign genes are increasing. Therefore, systems based on a single type of cells are no longer feasible. Synthetic biology approaches with multiple subpopulations of specifically functionalized cells, wired by artificial cell-cell communication systems, provide an attractive and powerful alternative. Here we review recent applications of synthetic cell-cell communication systems with a specific focus on recent advances with fungal hosts.

Keywords: Cell-cell communication; Cellular consortia; Signal molecule pathways; Synthetic biology; Synthetic circuit engineering

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