Display options
Cite
Tomioka H, Kaneoya A, Mochizuki Y, et al. Primary Diffuse Large B-cell Lymphoma Arising in the Tongue Accompanied by Ataxia-telangiectasia: A Case Report. J Clin Diagn Res. 2015;9(6):ZD25-7doi: 10.7860/JCDR/2015/12121.6107.
Tomioka, H., Kaneoya, A., Mochizuki, Y., & Harada, H. (2015). Primary Diffuse Large B-cell Lymphoma Arising in the Tongue Accompanied by Ataxia-telangiectasia: A Case Report. Journal of clinical and diagnostic research : JCDR, 9(6), ZD25-7. https://doi.org/10.7860/JCDR/2015/12121.6107
Tomioka, Hirofumi, et al. "Primary Diffuse Large B-cell Lymphoma Arising in the Tongue Accompanied by Ataxia-telangiectasia: A Case Report." Journal of clinical and diagnostic research : JCDR vol. 9,6 (2015): ZD25-7. doi: https://doi.org/10.7860/JCDR/2015/12121.6107
Tomioka H, Kaneoya A, Mochizuki Y, Harada H. Primary Diffuse Large B-cell Lymphoma Arising in the Tongue Accompanied by Ataxia-telangiectasia: A Case Report. J Clin Diagn Res. 2015 Jun;9(6):ZD25-7. doi: 10.7860/JCDR/2015/12121.6107. Epub 2015 Jun 01. PMID: 26266230; PMCID: PMC4525621.
Copy Download .nbib Format: NLM
Share it on

J Clin Diagn Res. 2015 Jun;9(6):ZD25-7. doi: 10.7860/JCDR/2015/12121.6107. Epub 2015 Jun 01.

Primary Diffuse Large B-cell Lymphoma Arising in the Tongue Accompanied by Ataxia-telangiectasia: A Case Report.

Journal of clinical and diagnostic research : JCDR

Hirofumi Tomioka, Ayano Kaneoya, Yumi Mochizuki, Hiroyuki Harada

Affiliations

  1. Assistant Professor, Oral and Maxillofacial Surgery, Department of Oral Restitution, Division of Oral Health Sciences, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University , Tokyo, Japan .
  2. Research Resident, Oral and Maxillofacial Surgery, Department of Oral Restitution, Division of Oral Health Sciences, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University , Tokyo, Japan .

PMID: 26266230 PMCID: PMC4525621 DOI: 10.7860/JCDR/2015/12121.6107

Abstract

Ataxia-telangiectasia (AT) is a rare autosomal recessive disorder that is characterized by progressive cerebellar ataxia, telangiectasia, immunodeficiency, and a predisposition to leukemia/lymphoma. Here we report a rare case of lymphoma of the tongue accompanied by AT. Tumour extirpation was performed and diffuse large B-cell lymphoma was diagnosed following pathologic examination. A whole-body survey showed no other enlarged lymph nodes or tumour. The female patient then received a modified dosage of COPAD (cyclophosphamide, vinblastine, pirarubicin, and prednisolone) plus rituximab to avoid severe complications. As of follow-up after 3 years and 5 months, she remains in complete remission. Patients showing AT need careful surveillance and long-term continuous follow-up.

Keywords: COPAD; Paediatrics; Tongue

References

  1. Blood. 1996 Jan 15;87(2):423-38 - PubMed
  2. Cancer Genet Cytogenet. 1990 Nov 1;50(1):119-23 - PubMed
  3. Br J Haematol. 2008 Jun;141(6):840-7 - PubMed
  4. Cancer. 2001 Oct 1;92(7):1959-66 - PubMed
  5. Oral Dis. 2010 Mar;16(2):119-28 - PubMed
  6. J Oral Med. 1986 Jul-Sep;41(3):197-200 - PubMed
  7. Hum Mol Genet. 1998;7(10):1555-63 - PubMed
  8. J Pediatr Hematol Oncol. 2004 Jul;26(7):444-6 - PubMed
  9. Med Pediatr Oncol. 1998 Dec;31(6):491-7 - PubMed

Publication Types