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Cruces P, Salas C, Lillo P, et al. The renal compartment: a hydraulic view. Intensive Care Med Exp. 2014;2(1):26doi: 10.1186/s40635-014-0026-x.
Cruces, P., Salas, C., Lillo, P., Salomon, T., Lillo, F., & Hurtado, D. E. (2014). The renal compartment: a hydraulic view. Intensive care medicine experimental, 2(1), 26. https://doi.org/10.1186/s40635-014-0026-x
Cruces, Pablo, et al. "The renal compartment: a hydraulic view." Intensive care medicine experimental vol. 2,1 (2014): 26. doi: https://doi.org/10.1186/s40635-014-0026-x
Cruces P, Salas C, Lillo P, Salomon T, Lillo F, Hurtado DE. The renal compartment: a hydraulic view. Intensive Care Med Exp. 2014 Dec;2(1):26. doi: 10.1186/s40635-014-0026-x. Epub 2014 Oct 23. PMID: 26266923; PMCID: PMC4512983.
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Intensive Care Med Exp. 2014 Dec;2(1):26. doi: 10.1186/s40635-014-0026-x. Epub 2014 Oct 23.

The renal compartment: a hydraulic view.

Intensive care medicine experimental

Pablo Cruces, Camila Salas, Pablo Lillo, Tatiana Salomon, Felipe Lillo, Daniel E Hurtado

Affiliations

  1. Centro de Investigación de Medicina Veterinaria, Escuela de Medicina Veterinaria, Facultad de Ecología y Recursos Naturales, Universidad Andres Bello, Av. República 237, Santiago, Chile, [email protected].

PMID: 26266923 PMCID: PMC4512983 DOI: 10.1186/s40635-014-0026-x

Abstract

BACKGROUND: The hydraulic behavior of the renal compartment is poorly understood. In particular, the role of the renal capsule on the intrarenal pressure has not been thoroughly addressed to date. We hypothesized that pressure and volume in the renal compartment are not linearly related, similar to other body compartments.

METHODS: The pressure-volume curve of the renal compartment was obtained by injecting fluid into the renal pelvis and recording the rise in intrarenal pressure in six anesthetized and mechanically ventilated piglets, using a catheter Camino 4B® inserted into the renal parenchyma.

RESULTS: In healthy kidneys, pressure has a highly nonlinear dependence on the injected volume, as revealed by an exponential fit to the data (R (2) = 0.92). On the contrary, a linear relation between pressure and volume is observed in decapsulated kidneys. We propose a biomechanical model for the renal capsule that is able to explain the nonlinear pressure-volume dependence for moderate volume increases.

CONCLUSIONS: We have presented experimental evidence and a theoretical model that supports the existence of a renal compartment. The mechanical role of the renal capsule investigated in this work may have important implications in elucidating the role of decompressive capsulotomy in reducing the intrarenal pressure in acutely injured kidneys.

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