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Hirano R, Sakamoto Y, Kudo K, et al. Retrospective analysis of mortality and Candida isolates of 75 patients with candidemia: a single hospital experience. Infect Drug Resist. 2015;8:199-205doi: 10.2147/IDR.S80677.
Hirano, R., Sakamoto, Y., Kudo, K., & Ohnishi, M. (2015). Retrospective analysis of mortality and Candida isolates of 75 patients with candidemia: a single hospital experience. Infection and drug resistance, 8199-205. https://doi.org/10.2147/IDR.S80677
Hirano, Ryuichi, et al. "Retrospective analysis of mortality and Candida isolates of 75 patients with candidemia: a single hospital experience." Infection and drug resistance vol. 8 (2015): 199-205. doi: https://doi.org/10.2147/IDR.S80677
Hirano R, Sakamoto Y, Kudo K, Ohnishi M. Retrospective analysis of mortality and Candida isolates of 75 patients with candidemia: a single hospital experience. Infect Drug Resist. 2015 Jul 08;8:199-205. doi: 10.2147/IDR.S80677. eCollection 2015. PMID: 26185460; PMCID: PMC4501221.
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Infect Drug Resist. 2015 Jul 08;8:199-205. doi: 10.2147/IDR.S80677. eCollection 2015.

Retrospective analysis of mortality and Candida isolates of 75 patients with candidemia: a single hospital experience.

Infection and drug resistance

Ryuichi Hirano, Yuichi Sakamoto, Kumiko Kudo, Motoki Ohnishi

Affiliations

  1. Department of Pharmacy, Aomori Prefectural Central Hospital, Aomori, Japan.
  2. Laboratory Medicine and Blood transfusion, Aomori Prefectural Central Hospital, Aomori, Japan.
  3. General Medicine, Aomori Prefectural Central Hospital, Aomori, Japan.

PMID: 26185460 PMCID: PMC4501221 DOI: 10.2147/IDR.S80677

Abstract

The mortality rate for candidemia is approximately 30%-60%. However, prognostic factors in patients with candidemia have not yet been elucidated in detail. The aim of the present study was to analyze prognostic factors for candidemia using the mortality rate and Candida isolates of patients with candidemia. Seventy-five patients with candidemia were analyzed between January 2007 and December 2013. The main outcome of this study was the 30-day mortality rate after the diagnosis of candidemia. The acute physiology and chronic health evaluation II score (APACHE II score) was measured in 34 patients (45.3%). Odds ratios (ORs) for death due to candidemia were analyzed using a multivariate stepwise logistic regression analysis. Twenty (26.6%) patients died within 30 days of being diagnosed with candidemia. Non-survivors had a significantly higher APACHE II score (n=7, mean; 18.9±4.5) than that of survivors (n=27, mean; 14.0±5.0). Advanced age (OR =1.1, 95% confidence interval =1.01-1.23, P=0.04) was a significant risk factor for a high mortality rate, whereas removal of a central venous catheter (OR =0.03, 95% confidence interval =0.002-0.3, P=0.01) was associated with a lower mortality rate. Seventy-six Candida spp. were isolated from blood cultures: Candida albicans 28 (36.8%), Candida parapsilosis 23 (30.2%), Candida guilliermondii 16 (21.0%), Candida glabrata four (5.2%), Candida tropicalis two (2.6%), and Candida spp. three (3.9%) that could not be identified. C. parapsilosis was the most frequently isolated species in younger patients (<65 years), whereas C. albicans was the most frequently isolated in elderly patients (≥65 years). Physicians who treat candidemia need to consider removing the central venous catheter and pay attention to the general condition of patients, particularly that of elderly patients.

Keywords: Candida; Japan; aging; candidemia; central venous catheter

References

  1. Ther Clin Risk Manag. 2014 Feb 13;10:95-105 - PubMed
  2. Antimicrob Agents Chemother. 2005 Sep;49(9):3640-5 - PubMed
  3. Intensive Care Med. 1988;14(5):558-66 - PubMed
  4. BMC Infect Dis. 2014 Nov 25;14:609 - PubMed
  5. Intensive Care Med. 2014 Oct;40(10):1489-98 - PubMed
  6. J Clin Microbiol. 2002 Mar;40(3):852-6 - PubMed
  7. J Clin Microbiol. 2012 Sep;50(9):2846-56 - PubMed
  8. Diagn Microbiol Infect Dis. 2012 Jun;73(2):149-52 - PubMed
  9. Am J Med. 1998 Mar;104(3):238-45 - PubMed
  10. Can J Infect Dis Med Microbiol. 2013 Fall;24(3):e65-8 - PubMed
  11. Clin Infect Dis. 1999 May;28(5):1071-9 - PubMed
  12. Eur J Clin Microbiol Infect Dis. 2004 May;23(5):380-8 - PubMed
  13. Eur J Clin Microbiol Infect Dis. 2002 Nov;21(11):767-74 - PubMed
  14. Clin Interv Aging. 2013;8:1199-208 - PubMed
  15. J Microbiol Immunol Infect. 2006 Apr;39(2):155-61 - PubMed
  16. J Antimicrob Chemother. 2013 Nov;68(11):2632-5 - PubMed
  17. Crit Care Med. 2008 Jul;36(7):2034-9 - PubMed
  18. Clin Infect Dis. 2004 Aug 1;39(3):309-17 - PubMed
  19. J Antimicrob Chemother. 2004 Feb;53(2):283-9 - PubMed
  20. J Infect. 2008 Feb;56(2):126-9 - PubMed
  21. Clin Infect Dis. 2012 Apr;54(8):1110-22 - PubMed
  22. Clin Infect Dis. 2012 Jun;54(12):1739-46 - PubMed
  23. Clin Infect Dis. 2009 Mar 1;48(5):503-35 - PubMed

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