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Ibrahim YM, Baker ES, Danielson WF, et al. Development of a New Ion Mobility (Quadrupole) Time-of-Flight Mass Spectrometer. Int J Mass Spectrom. 2015;377:655-662doi: 10.1016/j.ijms.2014.07.034.
Ibrahim, Y. M., Baker, E. S., Danielson, W. F., Norheim, R. V., Prior, D. C., Anderson, G. A., Belov, M. E., & Smith, R. D. (2015). Development of a New Ion Mobility (Quadrupole) Time-of-Flight Mass Spectrometer. International journal of mass spectrometry, 377655-662. https://doi.org/10.1016/j.ijms.2014.07.034
Ibrahim, Yehia M, et al. "Development of a New Ion Mobility (Quadrupole) Time-of-Flight Mass Spectrometer." International journal of mass spectrometry vol. 377 (2015): 655-662. doi: https://doi.org/10.1016/j.ijms.2014.07.034
Ibrahim YM, Baker ES, Danielson WF, Norheim RV, Prior DC, Anderson GA, Belov ME, Smith RD. Development of a New Ion Mobility (Quadrupole) Time-of-Flight Mass Spectrometer. Int J Mass Spectrom. 2015 Feb 01;377:655-662. doi: 10.1016/j.ijms.2014.07.034. PMID: 26185483; PMCID: PMC4501404.
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Int J Mass Spectrom. 2015 Feb 01;377:655-662. doi: 10.1016/j.ijms.2014.07.034.

Development of a New Ion Mobility (Quadrupole) Time-of-Flight Mass Spectrometer.

International journal of mass spectrometry

Yehia M Ibrahim, Erin S Baker, William F Danielson, Randolph V Norheim, David C Prior, Gordon A Anderson, Mikhail E Belov, Richard D Smith

Affiliations

  1. Biological Sciences Division, Pacific Northwest National Laboratory, P.O. Box 999 Richland, WA 99352.

PMID: 26185483 PMCID: PMC4501404 DOI: 10.1016/j.ijms.2014.07.034

Abstract

A new ion mobility spectrometer (IMS) platform was developed to improve upon the sensitivity and reproducibility of our previous platforms, and further enhance IMS-MS utility for broad 'pan-omics' measurements. The new platform incorporated an improved electrospray ionization source and interface for enhanced sensitivity, and providing the basis for further benefits based upon implementation of multiplexed IMS. The ion optics included electrodynamic ion funnels at both the entrance and exit of the IMS, an ion funnel trap for ion injection, and a design in which nearly all ion optics (e.g. drift rings, ion funnels) were fabricated using printed circuit board technology. The IMS resolving power achieved was ~73 for singly-charged ions, very close to the predicted diffusion-limited resolving power (~75). The platform's performance evaluation (e.g. for proteomics measurements) include LC-IMS-TOF MS datasets for 30 technical replicates for a trypsin digested human serum, and included platform performance in each dimension (LC, IMS and MS) separately.

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