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Ohlsson B, Melander O. Basal Plasma Levels of Copeptin are Elevated in Inactive Inflammatory Bowel Disease after Bowel Resection. Drug Target Insights. 2015;9:21-7doi: 10.4137/DTI.S26589.
Ohlsson, B., & Melander, O. (2015). Basal Plasma Levels of Copeptin are Elevated in Inactive Inflammatory Bowel Disease after Bowel Resection. Drug target insights, 921-7. https://doi.org/10.4137/DTI.S26589
Ohlsson, Bodil, and Melander, Olle. "Basal Plasma Levels of Copeptin are Elevated in Inactive Inflammatory Bowel Disease after Bowel Resection." Drug target insights vol. 9 (2015): 21-7. doi: https://doi.org/10.4137/DTI.S26589
Ohlsson B, Melander O. Basal Plasma Levels of Copeptin are Elevated in Inactive Inflammatory Bowel Disease after Bowel Resection. Drug Target Insights. 2015 Jul 13;9:21-7. doi: 10.4137/DTI.S26589. eCollection 2015. PMID: 26244009; PMCID: PMC4501700.
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Drug Target Insights. 2015 Jul 13;9:21-7. doi: 10.4137/DTI.S26589. eCollection 2015.

Basal Plasma Levels of Copeptin are Elevated in Inactive Inflammatory Bowel Disease after Bowel Resection.

Drug target insights

Bodil Ohlsson, Olle Melander

Affiliations

  1. Department of Clinical Sciences, Section of Internal Medicine, Skåne University Hospital, Malmö, and Lund University, Lund, Sweden.

PMID: 26244009 PMCID: PMC4501700 DOI: 10.4137/DTI.S26589

Abstract

Evidence of interactions between the enteric nervous system, neuropeptides, and the immune system is growing. The aim of this study was to examine basal plasma levels of a variety of peptide precursors in patients with inflammatory bowel disease (IBD). In two middle-aged cohorts, Malmö Preventive Medicine (n = 5,415) and Malmö Diet and Cost Study (n = 6,103), individuals with the diagnosis of IBD were identified. Medical records were scrutinized. Three controls were matched for each patient. Copeptin, midregional fragments of adrenomedullin, pro-atrial natriuretic peptide, and proenkephalin A, as well as N-terminal protachykinin A and proneurotensin were analyzed in the plasma. Sixty-two IBD patients were identified. The only difference between patients and controls was higher copeptin levels in the patients compared with controls (P = 0.006), with higher copeptin levels in resected than unresected patients (P = 0.020). There was no difference in any precursor levels between Crohn's disease and ulcerative colitis, between different distributions of disease lesions, or between different treatments.

Keywords: copeptin; inflammatory bowel disease; irritable bowel syndrome-like symptoms; neuropeptides; precursors

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