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Omenetti S, Brogi M, Goodman WA, et al. Dysregulated intrahepatic CD4. Cell Mol Gastroenterol Hepatol. 2015;1(4):406-419doi: 10.1016/j.jcmgh.2015.05.007.
Omenetti, S., Brogi, M., Goodman, W. A., Croniger, C. M., Eid, S., Huang, A. Y., Laffi, G., Roskams, T., Cominelli, F., Pinzani, M., & Pizarro, T. T. (2015). Dysregulated intrahepatic CD4. Cellular and molecular gastroenterology and hepatology, 1(4), 406-419. https://doi.org/10.1016/j.jcmgh.2015.05.007
Omenetti, Sara, et al. "Dysregulated intrahepatic CD4." Cellular and molecular gastroenterology and hepatology vol. 1,4 (2015): 406-419. doi: https://doi.org/10.1016/j.jcmgh.2015.05.007
Omenetti S, Brogi M, Goodman WA, Croniger CM, Eid S, Huang AY, Laffi G, Roskams T, Cominelli F, Pinzani M, Pizarro TT. Dysregulated intrahepatic CD4. Cell Mol Gastroenterol Hepatol. 2015 Jul 01;1(4):406-419. doi: 10.1016/j.jcmgh.2015.05.007. PMID: 26213712; PMCID: PMC4511857.
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Cell Mol Gastroenterol Hepatol. 2015 Jul 01;1(4):406-419. doi: 10.1016/j.jcmgh.2015.05.007.

Dysregulated intrahepatic CD4.

Cellular and molecular gastroenterology and hepatology

Sara Omenetti, Marco Brogi, Wendy A Goodman, Colleen M Croniger, Saada Eid, Alex Y Huang, Giacomo Laffi, Tania Roskams, Fabio Cominelli, Massimo Pinzani, Theresa T Pizarro

Affiliations

  1. Department of Pathology, Case Western Reserve University School of Medicine, Cleveland, OH, USA ; "DENOThe" Center, University of Florence, Florence, Italy.
  2. Department of Pathology, Case Western Reserve University School of Medicine, Cleveland, OH, USA.
  3. Department of Nutrition, Case Western Reserve University School of Medicine, Cleveland, OH, USA.
  4. Department of Pediatrics, Case Western Reserve University School of Medicine, Cleveland, OH, USA.
  5. Department of Pathology, Case Western Reserve University School of Medicine, Cleveland, OH, USA ; Department of Pediatrics, Case Western Reserve University School of Medicine, Cleveland, OH, USA.
  6. "DENOThe" Center, University of Florence, Florence, Italy.
  7. Department of Morphology and Molecular Pathology, University of Leuven, Leuven, Belgium.
  8. Department of Pathology, Case Western Reserve University School of Medicine, Cleveland, OH, USA ; Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, OH, USA ; "DENOThe" Center, University of Florence, Florence, Italy.
  9. Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, OH, USA ; "DENOThe" Center, University of Florence, Florence, Italy ; UCL Institute for Liver and Digestive Health, Royal Free Hospital, London, UK.

PMID: 26213712 PMCID: PMC4511857 DOI: 10.1016/j.jcmgh.2015.05.007

Abstract

BACKGROUND AND AIMS: Liver inflammation is a common extraintestinal manifestation of inflammatory bowel disease (IBD); however, whether liver involvement is a consequence of a primary intestinal defect or results from alternative pathogenic processes remains unclear. Therefore, we sought to determine the potential pathogenic mechanism(s) of concomitant liver inflammation in an established murine model of IBD.

METHODS: Liver inflammation and immune cell subsets were characterized in ileitis-prone SAMP1/YitFc (SAMP) and AKR/J (AKR) control mice, lymphocyte-depleted SAMP (SAMPx

RESULTS: Surprisingly, prominent inflammation was detected in 4-wk-old SAMP livers, prior to histologic evidence of ileitis, while both disease phenotypes were absent in age-matched AKRs. SAMP liver disease was characterized by abundant infiltration of lymphocytes, required for hepatic inflammation to occur, a Th1-skewed environment, and phenotypically-activated CD4

CONCLUSIONS: Activated intrahepatic CD4

Keywords: IBD-associated liver inflammation; SAMP1/YitFc mice; hepatic CD4+ T-cells; liver sinusoidal endothelial cells; regulatory T-cells

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