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Piskorska K, Sikora M, Gołaś M, et al. Invasive candidiasis serological diagnosis in solid organ transplant recipients. Cent Eur J Immunol. 2014;39(2):187-92doi: 10.5114/ceji.2014.43721.
Piskorska, K., Sikora, M., Gołaś, M., Dąbkowska, M., Pączek, L., & Swoboda-Kopeć, E. (2014). Invasive candidiasis serological diagnosis in solid organ transplant recipients. Central-European journal of immunology, 39(2), 187-92. https://doi.org/10.5114/ceji.2014.43721
Piskorska, Katarzyna, et al. "Invasive candidiasis serological diagnosis in solid organ transplant recipients." Central-European journal of immunology vol. 39,2 (2014): 187-92. doi: https://doi.org/10.5114/ceji.2014.43721
Piskorska K, Sikora M, Gołaś M, Dąbkowska M, Pączek L, Swoboda-Kopeć E. Invasive candidiasis serological diagnosis in solid organ transplant recipients. Cent Eur J Immunol. 2014;39(2):187-92. doi: 10.5114/ceji.2014.43721. Epub 2014 Jun 27. PMID: 26155122; PMCID: PMC4440018.
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Cent Eur J Immunol. 2014;39(2):187-92. doi: 10.5114/ceji.2014.43721. Epub 2014 Jun 27.

Invasive candidiasis serological diagnosis in solid organ transplant recipients.

Central-European journal of immunology

Katarzyna Piskorska, Magdalena Sikora, Marlena Gołaś, Maria Dąbkowska, Leszek Pączek, Ewa Swoboda-Kopeć

Affiliations

  1. Department of Medical Microbiology, Medical University of Warsaw, Warsaw, Poland.
  2. Department of Dental Microbiology, Medical University of Warsaw, Warsaw, Poland.
  3. Department of Immunology, Transplantology and Internal Medicine, Institute of Transplantology, Medical University of Warsaw, Warsaw, Poland.

PMID: 26155122 PMCID: PMC4440018 DOI: 10.5114/ceji.2014.43721

Abstract

Solid organ transplant recipients are at high risk of fungal infections, because of ongoing immunosuppressive treatment. There are three post organ transplant phases: early, intermediate, and late, all of them at risk of Candida infections. Since conventional tests are insufficient, specific secondary diagnostic tests are still being explored. Serological tests are currently the most common choice. The present study was to determine the usefulness of mannan antigen and anti-mannan antibody detection in diagnosing invasive candidiasis in liver or kidney transplant recipients. The levels of mannan and anti-mannan antibodies were assessed with Platelia Candida Ag Plus, and Platelia Candida Ab Plus (Biorad, Marne-la-Coquette, France) commercial tests, according to manufacturer's guidelines. Sixty six serum samples were obtained from 25 patients (9 liver transplant recipients, 7 kidney transplant recipients, and 9 patients prepared for a kidney transplant), 29 serum samples from 15 patients tested positive for mannan antigen. Serum samples were obtained from 14 patients tested positive for anti- mannan antibodies. Fungal antigen detection in blood serum in patients under immunosuppression, especially with neutropenia, suggests that antifungal treatment should be administered. Serological tests, especially mannan and anti-mannan ones, are very useful for confirmation or exclusion of invasive candidiasis in high-risk patients.

Keywords: antibody; antigen; serological tests

References

  1. Clin Microbiol Infect. 2010 Jul;16(7):855-62 - PubMed
  2. Eur J Clin Microbiol Infect Dis. 2007 Nov;26(11):755-66 - PubMed
  3. Clin Infect Dis. 2002 Mar 15;34(6):730-51 - PubMed
  4. J Clin Microbiol. 1999 May;37(5):1510-7 - PubMed
  5. Postepy Dermatol Alergol. 2013 Oct;30(5):293-301 - PubMed
  6. J Med Microbiol. 2009 May;58(Pt 5):606-15 - PubMed
  7. J Clin Microbiol. 2005 May;43(5):2181-7 - PubMed
  8. Mycoses. 2002 Dec;45(11-12):455-60 - PubMed
  9. J Clin Microbiol. 2003 Oct;41(10):4551-8 - PubMed
  10. Clin Infect Dis. 2010 Apr 15;50(8):1101-11 - PubMed
  11. J Med Microbiol. 2002 May;51(5):433-42 - PubMed
  12. Diagn Microbiol Infect Dis. 2005 Feb;51(2):95-101 - PubMed
  13. Clin Infect Dis. 2002 Jan 1;34(1):7-14 - PubMed
  14. Clin Infect Dis. 2000 Apr;30(4):662-78 - PubMed
  15. Eur J Clin Microbiol Infect Dis. 2001 Dec;20(12):864-70 - PubMed
  16. Przegl Epidemiol. 2003;57(2):299-307 - PubMed

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