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Malutan AM, Drugan T, Costin N, et al. Pro-inflammatory cytokines for evaluation of inflammatory status in endometriosis. Cent Eur J Immunol. 2015;40(1):96-102doi: 10.5114/ceji.2015.50840.
Malutan, A. M., Drugan, T., Costin, N., Ciortea, R., Bucuri, C., Rada, M. P., & Mihu, D. (2015). Pro-inflammatory cytokines for evaluation of inflammatory status in endometriosis. Central-European journal of immunology, 40(1), 96-102. https://doi.org/10.5114/ceji.2015.50840
Malutan, Andrei M, et al. "Pro-inflammatory cytokines for evaluation of inflammatory status in endometriosis." Central-European journal of immunology vol. 40,1 (2015): 96-102. doi: https://doi.org/10.5114/ceji.2015.50840
Malutan AM, Drugan T, Costin N, Ciortea R, Bucuri C, Rada MP, Mihu D. Pro-inflammatory cytokines for evaluation of inflammatory status in endometriosis. Cent Eur J Immunol. 2015;40(1):96-102. doi: 10.5114/ceji.2015.50840. Epub 2015 Apr 22. PMID: 26155190; PMCID: PMC4472546.
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Cent Eur J Immunol. 2015;40(1):96-102. doi: 10.5114/ceji.2015.50840. Epub 2015 Apr 22.

Pro-inflammatory cytokines for evaluation of inflammatory status in endometriosis.

Central-European journal of immunology

Andrei M Malutan, Tudor Drugan, Nicolae Costin, Razvan Ciortea, Carmen Bucuri, Maria P Rada, Dan Mihu

Affiliations

  1. "Iuliu Hatieganu" University of Medicine and Pharmacy, Cluj-Napoca, Romania.

PMID: 26155190 PMCID: PMC4472546 DOI: 10.5114/ceji.2015.50840

Abstract

THE AIM OF THE STUDY: The aim of the study was to investigate the serum pro-inflammatory cytokine profile in patients with diagnosed endometriosis.

MATERIAL AND METHODS: The study included 160 women, who were divided in two study groups (Group I - endometriosis; Group 2 - healthy). We evaluated the serum levels of interleukin (IL)-1β, IL-5, IL-6, IL-7, and IL-12, and of tumour necrosis factor α (TNF-α) with the use of Human Multiplex Cytokine Panels.

RESULTS: The serum level of IL-1β, IL-6, and TNF-α is significantly higher in women with endometriosis compared to women free of disease, from the control group (mean 10.777, 183.027, and 131.326, respectively, compared to 3.039, 70.043, and 75.285, respectively; p = 0.002, p < 0.001, and p = 0.015, respectively). No significant differences in the serum levels of IL-5 and IL-12 were observed between the studied groups, and IL-7 had a very low detection rate.

CONCLUSIONS: Women with endometriosis have elevated levels of key pro-inflammatory cytokines, i.e. IL-1β, IL-6, and TNF-α. At the same time, IL-1β and IL-6 could be used as predictors for endometriosis.

Keywords: cytokine; endometriosis; inflammation; interleukin

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