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van der Waart AB, Hobo W, Dolstra H. Time to . Oncoimmunology. 2015;4(5):e1003016doi: 10.1080/2162402X.2014.1003016.
van der Waart, A. B., Hobo, W., & Dolstra, H. (2015). Time to . Oncoimmunology, 4(5), e1003016. https://doi.org/10.1080/2162402X.2014.1003016
van der Waart, Anniek B, et al. "Time to ." Oncoimmunology vol. 4,5 (2015): e1003016. doi: https://doi.org/10.1080/2162402X.2014.1003016
van der Waart AB, Hobo W, Dolstra H. Time to . Oncoimmunology. 2015 Feb 03;4(5):e1003016. doi: 10.1080/2162402X.2014.1003016. eCollection 2015 May. PMID: 26155398; PMCID: PMC4485741.
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Oncoimmunology. 2015 Feb 03;4(5):e1003016. doi: 10.1080/2162402X.2014.1003016. eCollection 2015 May.

Time to .

Oncoimmunology

Anniek B van der Waart, Willemijn Hobo, Harry Dolstra

Affiliations

  1. Department of Laboratory Medicine - Laboratory of Hematology; Radboud university medical center ; Nijmegen, The Netherlands.

PMID: 26155398 PMCID: PMC4485741 DOI: 10.1080/2162402X.2014.1003016

Abstract

T cells are crucial players in the protection against cancer, and can be used in adoptive cell therapy to prevent or treat relapse. However, their state of differentiation determines their effectiveness, with early memory cells being the most favorable. Here, we discuss restraining of differentiation to engineer the ultimate tumor-reactive T cell.

Keywords: ACT: adoptive cell therapy; APC: antigen-presenting cells; Akt; Allo-SCT: allogeneic stem cell transplantation; CAR: chimeric antigen receptor; DCs: dendritic cells; IL-15; IL-7; MiHAs: minor histocompatibility antigens; T-cell differentiation; TCR: T-cell receptor; TILs: tumor-infiltrating lymphocytes; Tcm: central memory T; Teff: effector T; Tem: effector memory T; Tn: naive T; Tscm: stem cell memory T; Wnt; adoptive T cell therapy; dendritic cell; stem cell transplantation

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