Display options
Cite
Robino A, Bevilacqua L, Pirastu N, et al. Polymorphisms in sweet taste genes (TAS1R2 and GLUT2), sweet liking, and dental caries prevalence in an adult Italian population. Genes Nutr. 2015;10(5):485doi: 10.1007/s12263-015-0485-z.
Robino, A., Bevilacqua, L., Pirastu, N., Situlin, R., Di Lenarda, R., Gasparini, P., & Navarra, C. O. (2015). Polymorphisms in sweet taste genes (TAS1R2 and GLUT2), sweet liking, and dental caries prevalence in an adult Italian population. Genes & nutrition, 10(5), 485. https://doi.org/10.1007/s12263-015-0485-z
Robino, Antonietta, et al. "Polymorphisms in sweet taste genes (TAS1R2 and GLUT2), sweet liking, and dental caries prevalence in an adult Italian population." Genes & nutrition vol. 10,5 (2015): 485. doi: https://doi.org/10.1007/s12263-015-0485-z
Robino A, Bevilacqua L, Pirastu N, Situlin R, Di Lenarda R, Gasparini P, Navarra CO. Polymorphisms in sweet taste genes (TAS1R2 and GLUT2), sweet liking, and dental caries prevalence in an adult Italian population. Genes Nutr. 2015 Sep;10(5):485. doi: 10.1007/s12263-015-0485-z. Epub 2015 Aug 13. PMID: 26268603; PMCID: PMC4534477.
Copy Download .nbib Format: NLM
Share it on

Genes Nutr. 2015 Sep;10(5):485. doi: 10.1007/s12263-015-0485-z. Epub 2015 Aug 13.

Polymorphisms in sweet taste genes (TAS1R2 and GLUT2), sweet liking, and dental caries prevalence in an adult Italian population.

Genes & nutrition

Antonietta Robino, Lorenzo Bevilacqua, Nicola Pirastu, Roberta Situlin, Roberto Di Lenarda, Paolo Gasparini, Chiara Ottavia Navarra

Affiliations

  1. Institute for Maternal and Child Health - IRCCS "Burlo Garofolo", Via dell'Istria 65/1, 34137, Trieste, Italy, [email protected].

PMID: 26268603 PMCID: PMC4534477 DOI: 10.1007/s12263-015-0485-z

Abstract

The aim of the study was to assess the relationship between sweet taste genes and dental caries prevalence in a large sample of adults. In addition, the association between sweet liking and sugar intake with dental caries was investigated. Caries was measured by the decayed, missing, filled teeth (DMFT) index in 647 Caucasian subjects (285 males and 362 females, aged 18-65 years), coming from six villages in northeastern Italy. Sweet liking was assessed using a 9-point scale, and the mean of the liking given by each individual to specific sweet food and beverages was used to create a sweet liking score. Simple sugar consumption was estimated by a dietary history interview, considering both added sugars and sugar present naturally in foods. Our study confirmed that polymorphisms in TAS1R2 and GLUT2 genes are related to DMFT index. In particular, GG homozygous individuals for rs3935570 in TAS1R2 gene (p value = 0.0117) and GG homozygous individuals for rs1499821 in GLUT2 gene (p value = 0.0273) showed higher DMFT levels compared to both heterozygous and homozygous for the alternative allele. Furthermore, while the relationship sugar intake-DMFT did not achieve statistical significance (p value = 0.075), a significant association was identified between sweet liking and DMFT (p value = 0.004), independent of other variables. Our study showed that sweet taste genetic factors contribute to caries prevalence and highlighted the role of sweet liking as a predictor of caries risk. Therefore, these results may open new perspectives for individual risk identification and implementation of target preventive strategies, such as identifying high-risk patients before caries development.

References

  1. Lancet. 2012 Dec 15;380(9859):2163-96 - PubMed
  2. Physiol Behav. 2006 Feb 28;87(2):304-13 - PubMed
  3. Chem Senses. 2013 Jun;38(5):379-89 - PubMed
  4. J Am Dent Assoc. 2008 Jul;139(7):959-67; quiz 995 - PubMed
  5. Gerodontology. 1993 Dec;10(2):90-7 - PubMed
  6. BMC Med Genet. 2013 Nov 05;14:116 - PubMed
  7. BMC Oral Health. 2012 Dec 21;12:57 - PubMed
  8. Chem Senses. 2011 Mar;36(3):311-9 - PubMed
  9. Eur J Oral Sci. 2001 Jun;109(3):143-8 - PubMed
  10. Bioinformatics. 2007 May 15;23(10):1294-6 - PubMed
  11. Chemosens Percept. 2010 Dec 1;3(3-4):137-148 - PubMed
  12. J Dent Res. 2013 Jul;92(7):592-7 - PubMed
  13. Physiol Genomics. 2008 May 13;33(3):355-60 - PubMed
  14. Food Qual Prefer. 2013 Dec;30(2):202-216 - PubMed
  15. Int Dent J. 1997 Aug;47(4):213-7 - PubMed
  16. Am J Epidemiol. 2007 Sep 1;166(5):576-81 - PubMed
  17. PLoS One. 2014 Mar 19;9(3):e92065 - PubMed
  18. Ann N Y Acad Sci. 2009 Jul;1170:558-68 - PubMed
  19. Arch Oral Biol. 1993 Nov;38(11):937-43 - PubMed
  20. Caries Res. 2006;40(6):459-65 - PubMed
  21. Caries Res. 1975;9(1):1-20 - PubMed
  22. J Dent Res. 2005 Aug;84(8):711-4 - PubMed
  23. Caries Res. 2001 Nov-Dec;35(6):442-50 - PubMed
  24. J Dent Res. 2001 Sep;80(9):1785-8 - PubMed
  25. Caries Res. 1994;28(6):477-83 - PubMed
  26. Caries Res. 2013;47(3):219-25 - PubMed
  27. Public Health Nutr. 2004 Feb;7(1A):201-26 - PubMed
  28. Nat Genet. 2012 Jul 22;44(8):955-9 - PubMed
  29. J Appl Oral Sci. 2010 Mar-Apr;18(2):166-70 - PubMed
  30. J Dent Res. 2005 Nov;84(11):1047-51 - PubMed
  31. J Inherit Metab Dis. 2000 May;23(3):237-46 - PubMed
  32. Br Dent J. 2013 Oct;215(7):E12 - PubMed
  33. Am J Clin Nutr. 2010 Dec;92 (6):1501-10 - PubMed
  34. J Public Health Dent. 1994 Summer;54(3):160-6 - PubMed
  35. Cell. 2001 Aug 10;106(3):381-90 - PubMed
  36. Appetite. 2002 Feb;38(1):3-12 - PubMed
  37. Arch Oral Biol. 1996 Mar;41(3):271-80 - PubMed
  38. Community Dent Oral Epidemiol. 1995 Jun;23 (3):142-6 - PubMed
  39. Caries Res. 1979;13(5):298-300 - PubMed
  40. Alcohol Clin Exp Res. 2004 Nov;28(11):1629-37 - PubMed
  41. Community Dent Oral Epidemiol. 1982 Feb;10 (1):1-7 - PubMed
  42. Annu Rev Nutr. 2008;28:367-88 - PubMed
  43. Arch Oral Biol. 2006 Dec;51(12):1156-60 - PubMed
  44. Community Dent Oral Epidemiol. 1984 Dec;12(6):386-9 - PubMed
  45. J Am Diet Assoc. 1994 Dec;94(12):1392-7 - PubMed
  46. Alcohol Clin Exp Res. 2014 Oct;38(10):2550-60 - PubMed
  47. Community Dent Health. 2001 Jun;18(2):72-8 - PubMed
  48. Eur J Hum Genet. 2013 Jun;21(6):659-65 - PubMed
  49. J Am Diet Assoc. 2007 Feb;107(2):237-45 - PubMed
  50. Arch Gerontol Geriatr. 2012 Mar-Apr;54(2):e13-8 - PubMed
  51. Caries Res. 1999;33(2):101-13 - PubMed
  52. J Dent Res. 1988 Nov;67(11):1422-9 - PubMed
  53. Community Dent Health. 1999 Jun;16(2):68-71 - PubMed
  54. Caries Res. 2008;42(1):8-13 - PubMed
  55. J Dent Res. 2010 Nov;89(11):1198-202 - PubMed
  56. Int Dent J. 2003 Oct;53(5):285-8 - PubMed
  57. Science. 2003 Feb 21;299(5610):1221-5 - PubMed
  58. J Am Diet Assoc. 1999 Dec;99(12):1529-35 - PubMed
  59. Community Dent Oral Epidemiol. 1998 Apr;26(2):115-21 - PubMed
  60. Am J Public Health. 2014 Jul;104(7):e115-21 - PubMed
  61. J Am Diet Assoc. 2003 May;103(5):615-25 - PubMed
  62. Int Dent J. 2008 Jun;58(3):115-21 - PubMed
  63. Arterioscler Thromb Vasc Biol. 2008 Jan;28(1):173-9 - PubMed

Publication Types