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Wasihun AG, Wlekidan LN, Gebremariam SA, et al. Bacteriological profile and antimicrobial susceptibility patterns of blood culture isolates among febrile patients in Mekelle Hospital, Northern Ethiopia. Springerplus. 2015;4:314doi: 10.1186/s40064-015-1056-x.
Wasihun, A. G., Wlekidan, L. N., Gebremariam, S. A., Dejene, T. A., Welderufael, A. L., Haile, T. D., & Muthupandian, S. (2015). Bacteriological profile and antimicrobial susceptibility patterns of blood culture isolates among febrile patients in Mekelle Hospital, Northern Ethiopia. SpringerPlus, 4314. https://doi.org/10.1186/s40064-015-1056-x
Wasihun, Araya Gebreyesus, et al. "Bacteriological profile and antimicrobial susceptibility patterns of blood culture isolates among febrile patients in Mekelle Hospital, Northern Ethiopia." SpringerPlus vol. 4 (2015): 314. doi: https://doi.org/10.1186/s40064-015-1056-x
Wasihun AG, Wlekidan LN, Gebremariam SA, Dejene TA, Welderufael AL, Haile TD, Muthupandian S. Bacteriological profile and antimicrobial susceptibility patterns of blood culture isolates among febrile patients in Mekelle Hospital, Northern Ethiopia. Springerplus. 2015 Jul 03;4:314. doi: 10.1186/s40064-015-1056-x. eCollection 2015. PMID: 26155453; PMCID: PMC4489972.
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Springerplus. 2015 Jul 03;4:314. doi: 10.1186/s40064-015-1056-x. eCollection 2015.

Bacteriological profile and antimicrobial susceptibility patterns of blood culture isolates among febrile patients in Mekelle Hospital, Northern Ethiopia.

SpringerPlus

Araya Gebreyesus Wasihun, Letemichael Negash Wlekidan, Senay Aregawi Gebremariam, Tsehaye Asmelash Dejene, Abadi Luel Welderufael, Tadesse Dejenie Haile, Saravanan Muthupandian

Affiliations

  1. Department of Medical Microbiology and Immunology, Institute of Biomedical Sciences, College of Health Sciences, Mekelle University, 1871 Mekelle, Ethiopia.
  2. Department of Internal Medicine, School of Medicine, College of Health Sciences, Mekelle University, Mekelle, Ethiopia.
  3. Department of Pediatric Medicine, School of Medicine, College of Health Sciences, Mekelle University, Mekelle, Ethiopia.
  4. Department of Biology, College Natural and Computational Sciences, Mekelle University, Mekelle, Ethiopia.

PMID: 26155453 PMCID: PMC4489972 DOI: 10.1186/s40064-015-1056-x

Abstract

Bacterial bloodstream infections are a major public health problem, which leads to high morbidity and mortality of patients. On time diagnosis and appropriate medication will be the best way to save the lives of affected ones. The aim of the present study was to determine the bacterial profile of bloodstream infections and their antibiotic susceptibility pattern in Mekelle Hospital. Cross sectional study method was carried out in 514 (269 females and 245 males) febrile patients in Mekelle hospital from March to October 2014. Standard bacteriological methods were used for blood collection, bacterial isolation and antimicrobial susceptibility pattern. Out of the total 514 febrile patients, 144 (28%) culture positive were isolated. Staphylococcus aureus 54 (37.5%), Coagulase-negative staphylococci 44 (30.6%), Escherichia coli 16 (3.1%), Citrobacter spp. 9 (1.7%) and Salmonella typhi 8 (1.6%) were the most dominant isolates, collectively accounting for >90% of the isolates. Antimicrobial resistance pattern for gram positive and gram negative bacteria was 0-83.3% and 0-100%, respectively. High resistance was seen to Trimethoprim-sulphamethoxazole 101 (70.1%), Oxacillin 65 (62.5%), Ceftriaxone 79 (58.9%) and Doxycycline 71 (49.3%). Fifty-nine percent of the isolated bacteria in this study were multi drug resistant. Most bacterial isolates were sensitive to Gentamicin, Ciprofloxacin and Amoxicillin clavulanic acid. All gram positive isolates in this current study were sensitive to vancomycin. Prevalence of bacterial isolates in blood was high. It also reveals isolated bacteria species developed multi drug resistance to most of the antibiotics tested, which highlights for periodic surveillance of etiologic agent, antibiotic susceptibility to prevent further emergence and spread of resistant bacterial pathogens.

Keywords: Antimicrobial susceptibility pattern; Bacterial isolates; Blood culture; Febrile patients; Mekelle hospital; Multidrug resistance; Prevalence

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