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Tominari T, Matsumoto C, Watanabe K, et al. Epigallocatechin gallate (EGCG) suppresses lipopolysaccharide-induced inflammatory bone resorption, and protects against alveolar bone loss in mice. FEBS Open Bio. 2015;5:522-7doi: 10.1016/j.fob.2015.06.003.
Tominari, T., Matsumoto, C., Watanabe, K., Hirata, M., Grundler, F. M., Miyaura, C., & Inada, M. (2015). Epigallocatechin gallate (EGCG) suppresses lipopolysaccharide-induced inflammatory bone resorption, and protects against alveolar bone loss in mice. FEBS open bio, 5522-7. https://doi.org/10.1016/j.fob.2015.06.003
Tominari, Tsukasa, et al. "Epigallocatechin gallate (EGCG) suppresses lipopolysaccharide-induced inflammatory bone resorption, and protects against alveolar bone loss in mice." FEBS open bio vol. 5 (2015): 522-7. doi: https://doi.org/10.1016/j.fob.2015.06.003
Tominari T, Matsumoto C, Watanabe K, Hirata M, Grundler FM, Miyaura C, Inada M. Epigallocatechin gallate (EGCG) suppresses lipopolysaccharide-induced inflammatory bone resorption, and protects against alveolar bone loss in mice. FEBS Open Bio. 2015 Jun 12;5:522-7. doi: 10.1016/j.fob.2015.06.003. eCollection 2015. PMID: 26155460; PMCID: PMC4491591.
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FEBS Open Bio. 2015 Jun 12;5:522-7. doi: 10.1016/j.fob.2015.06.003. eCollection 2015.

Epigallocatechin gallate (EGCG) suppresses lipopolysaccharide-induced inflammatory bone resorption, and protects against alveolar bone loss in mice.

FEBS open bio

Tsukasa Tominari, Chiho Matsumoto, Kenta Watanabe, Michiko Hirata, Florian M W Grundler, Chisato Miyaura, Masaki Inada

Affiliations

  1. Department of Biotechnology and Life Science, Tokyo University of Agriculture and Technology, 2-24-16 Nakamachi, Koganei, Tokyo 184-8588, Japan ; Global Innovation Research Organization, Tokyo University of Agriculture and Technology, 2-24-16 Nakamachi, Koganei, Tokyo 184-8588, Japan.
  2. Department of Biotechnology and Life Science, Tokyo University of Agriculture and Technology, 2-24-16 Nakamachi, Koganei, Tokyo 184-8588, Japan.
  3. Institute of Crop Science and Resource Conservation, University of Bonn, Karlrobert-Kreiten-Strasse 13, 53115 Bonn, Germany.

PMID: 26155460 PMCID: PMC4491591 DOI: 10.1016/j.fob.2015.06.003

Abstract

Epigallocatechin gallate (EGCG), a major polyphenol in green tea, possesses antioxidant properties and regulates various cell functions. Here, we examined the function of EGCG in inflammatory bone resorption. In calvarial organ cultures, lipopolysaccharide (LPS)-induced bone resorption was clearly suppressed by EGCG. In osteoblasts, EGCG suppressed the LPS-induced expression of COX-2 and mPGES-1 mRNAs, as well as prostaglandin E2 production, and also suppressed RANKL expression, which is essential for osteoclast differentiation. LPS-induced bone resorption of mandibular alveolar bones was attenuated by EGCG in vitro, and the loss of mouse alveolar bone mass was inhibited by the catechin in vivo.

Keywords: BMN, bone mineral density; Bone resorption; COX, cyclo-oxygenase; EGCG, (−)-epigallocatechin-3-gallate; Epigallocatechin gallate; LPS, lipopolysaccharide; Lipopolysaccharide; OCPC, o-cresolphthalein complexon; OPG, osteoprotegerin; Osteoblasts; PGE2, prostaglandin E2; PSD, polymicrobial synergy and dysbiosis; Periodontitis; Prostaglandin E; RANKL, receptor activator of NF-kB ligand; mPGES, membrane-bound PGE synthase

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