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Suthar KS, Vanikar AV, Trivedi HL. Acute Kidney Injury and Quadriparesis Due to Rosuvastatin Induced Rhabdomyolysis- A Case Report. J Clin Diagn Res. 2015;9(5):OD08-9doi: 10.7860/JCDR/2015/12117.5909.
Suthar, K. S., Vanikar, A. V., & Trivedi, H. L. (2015). Acute Kidney Injury and Quadriparesis Due to Rosuvastatin Induced Rhabdomyolysis- A Case Report. Journal of clinical and diagnostic research : JCDR, 9(5), OD08-9. https://doi.org/10.7860/JCDR/2015/12117.5909
Suthar, Kamlesh S, et al. "Acute Kidney Injury and Quadriparesis Due to Rosuvastatin Induced Rhabdomyolysis- A Case Report." Journal of clinical and diagnostic research : JCDR vol. 9,5 (2015): OD08-9. doi: https://doi.org/10.7860/JCDR/2015/12117.5909
Suthar KS, Vanikar AV, Trivedi HL. Acute Kidney Injury and Quadriparesis Due to Rosuvastatin Induced Rhabdomyolysis- A Case Report. J Clin Diagn Res. 2015 May;9(5):OD08-9. doi: 10.7860/JCDR/2015/12117.5909. Epub 2015 May 01. PMID: 26155510; PMCID: PMC4484102.
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J Clin Diagn Res. 2015 May;9(5):OD08-9. doi: 10.7860/JCDR/2015/12117.5909. Epub 2015 May 01.

Acute Kidney Injury and Quadriparesis Due to Rosuvastatin Induced Rhabdomyolysis- A Case Report.

Journal of clinical and diagnostic research : JCDR

Kamlesh S Suthar, Aruna V Vanikar, Hargovind L Trivedi

Affiliations

  1. Assistant Professor, Department of Pathology, Laboratory Medicine, Transfusion Services and Immunohematology, G.R. Doshi and K.M. Mehta Institute of Kidney Diseases and Research Centre and Dr. H.L. Trivedi Institute of Transplantation Sciences (IKDRC-ITS) , Ahmedabad, India .
  2. Professor, Department of Pathology, Laboratory Medicine, Transfusion Services and Immunohematology, G.R. Doshi and K.M. Mehta Institute of Kidney Diseases and Research Centre and Dr. H.L. Trivedi Institute of Transplantation Sciences (IKDRC-ITS) , Ahmedabad, India .
  3. Professor, Department of Nephrology and Transplantation Medicine, (IKDRC-ITS) , Ahmedabad, India .

PMID: 26155510 PMCID: PMC4484102 DOI: 10.7860/JCDR/2015/12117.5909

Abstract

Statins as lipid lowering drugs, are safe and effective in reducing cardiovascular disease risk, but rarely produce myopathy like myalgia, myositis or rhabdomyolysis. We report the case of Rosuvastatin induced rhabdomyolytic acute renal failure and quadriparesis in a 67-year old male, a known case of type-2 diabetes mellitus and with a history of coronary angioplasty four months back. He was on antihypertensive, oral hypoglycemic and antiplatelet medications with Rosuvastatin 40mg/day. He was admitted with altered sensorium, breathlessness, vomiting, muscle weakness and decreased urine output and had raised serum creatinine, creatinine phosphokinase and myoglobin. After ruling out all other causation for rhabdomyolysis, we stopped Rosuvastatin and started supportive management and hemodialysis. Patient showed gradual recovery in renal function and quadriparesis. Patient was discharged with good urine output and on antihypertensive, hypoglycemic drug and diet restrictions for lipid control. He recovered completely and had normal renal function with well controlled lipid level on follow up of 6 months after discharge. Thus, prompt diagnosis of Rhabdomyolysis due to Rosuvastatin in absence of other aetiology and the multidisciplinary management can prevent further complication with favorable outcome.

Keywords: Acute renal failure; Muscular diseases; Statin

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