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Gozukara IO, Gozukara KH, Kucur SK, et al. Association of Glomerular Filtration Rate with Inflammation in Polycystic Ovary Syndrome. Int J Fertil Steril. 2015;9(2):176-82doi: 10.22074/ijfs.2015.4238.
Gozukara, I. O., Gozukara, K. H., Kucur, S. K., Karakılıc, E. U., Keskin, H., Akdeniz, D., Aksoy, A. N., & Carlıoglu, A. (2015). Association of Glomerular Filtration Rate with Inflammation in Polycystic Ovary Syndrome. International journal of fertility & sterility, 9(2), 176-82. https://doi.org/10.22074/ijfs.2015.4238
Gozukara, Ilay Ozturk, et al. "Association of Glomerular Filtration Rate with Inflammation in Polycystic Ovary Syndrome." International journal of fertility & sterility vol. 9,2 (2015): 176-82. doi: https://doi.org/10.22074/ijfs.2015.4238
Gozukara IO, Gozukara KH, Kucur SK, Karakılıc EU, Keskin H, Akdeniz D, Aksoy AN, Carlıoglu A. Association of Glomerular Filtration Rate with Inflammation in Polycystic Ovary Syndrome. Int J Fertil Steril. 2015 Jul-Sep;9(2):176-82. doi: 10.22074/ijfs.2015.4238. Epub 2015 Jul 27. PMID: 26246875; PMCID: PMC4518485.
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Int J Fertil Steril. 2015 Jul-Sep;9(2):176-82. doi: 10.22074/ijfs.2015.4238. Epub 2015 Jul 27.

Association of Glomerular Filtration Rate with Inflammation in Polycystic Ovary Syndrome.

International journal of fertility & sterility

Ilay Ozturk Gozukara, Kerem Han Gozukara, Suna Kabil Kucur, Eda Ulku Karakılıc, Havva Keskin, Derya Akdeniz, Ayse Nur Aksoy, Ayse Carlıoglu

Affiliations

  1. Department of Obstetric and Gynecology, Dumlup?nar University Medical Faculty Hospital , Kütahya, Turkey.
  2. Department of Urology, Palandöken Hospital, Erzurum, Turkey.
  3. Department of Obstetric and Gynecology, Nenehatun Women Health Hospital, Erzurum, Turkey.
  4. Department of Internal Medicine, Erzurum Bölge Training and Research Hospital, Erzurum, Turkey.
  5. Department of Internal Medicine, Fatih University Medical Faculty Hospital, Ankara, Turkey.

PMID: 26246875 PMCID: PMC4518485 DOI: 10.22074/ijfs.2015.4238

Abstract

BACKGROUND: We aimed to estimate the glomerular filtration rate (GFR) in women with polycystic ovary syndrome (PCOS) and to determine the relationship between GFR with C-reactive protein (CRP) and uric acid.

MATERIALS AND METHODS: In this cross-sectional study, one-hundred and forty PCOS women and 60 healthy subjects were evaluated. The study was carried out at Endocrinol- ogy Outpatient Clinic, Erzurum Training and Research Hospital, Erzurum, Turkey, from December 2010 to January 2011. GFRs were estimated by Modification of Diet in Renal Disease (MDRD) formula. CRP, urinary albumin excretion (UAE) and uric acid levels were also measured.

RESULTS: GFRs were significantly higher in PCOS group than control (135.24 ± 25.62 vs. 114.92 ± 24.07 ml/min per 1.73 m(2)). CRP levels were significantly higher in PCOS patients (4.4 ± 3.4 vs. 2.12 ± 1.5 mg/l). The PCOS group had significantly higher serum uric acid levels (4.36 ± 1.3 mg/dl vs. 3.2 ± 0.73 mg/dl). There was also significantly higher proteinuria level in PCOS patients.

CONCLUSION: Even though PCOS patients had higher GFR, serum uric acid and UAE val- ues than control patients, the renal function was within normal limits. Increased GFR in PCOS women positively correlates with elevated serum CRP and uric acid.

Keywords: CRP; Glomerular Filtration Rate; Polycystic Ovary Syndrome; Uric Acid

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