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Rothenberg ME, Araya H, Longacre TA, et al. Lanthanum-Induced Gastrointestinal Histiocytosis. ACG Case Rep J. 2015;2(3):187-9doi: 10.14309/crj.2015.50.
Rothenberg, M. E., Araya, H., Longacre, T. A., & Pasricha, P. J. (2015). Lanthanum-Induced Gastrointestinal Histiocytosis. ACG case reports journal, 2(3), 187-9. https://doi.org/10.14309/crj.2015.50
Rothenberg, Michael E, et al. "Lanthanum-Induced Gastrointestinal Histiocytosis." ACG case reports journal vol. 2,3 (2015): 187-9. doi: https://doi.org/10.14309/crj.2015.50
Rothenberg ME, Araya H, Longacre TA, Pasricha PJ. Lanthanum-Induced Gastrointestinal Histiocytosis. ACG Case Rep J. 2015 Apr 10;2(3):187-9. doi: 10.14309/crj.2015.50. eCollection 2015 Apr. PMID: 26157959; PMCID: PMC4435400.
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ACG Case Rep J. 2015 Apr 10;2(3):187-9. doi: 10.14309/crj.2015.50. eCollection 2015 Apr.

Lanthanum-Induced Gastrointestinal Histiocytosis.

ACG case reports journal

Michael E Rothenberg, Hiwot Araya, Teri A Longacre, Pankaj J Pasricha

Affiliations

  1. Gastroenterology and Hepatology, Department of Medicine, Stanford University School of Medicine, Stanford, CA.
  2. Department of Medicine, Stanford University School of Medicine, Stanford, CA.
  3. Department of Pathology, Stanford University School of Medicine, Stanford, CA.
  4. Department of Gastroenterology and Hepatology, Johns Hopkins University School of Medicine, Baltimore, MD.

PMID: 26157959 PMCID: PMC4435400 DOI: 10.14309/crj.2015.50

Abstract

A patient with end-stage renal disease (ESRD) on hemodialysis presented with fever, anorexia, and nausea shortly after starting oral lanthanum carbonate for phosphate control. Gastric and duodenal biopsies demonstrated diffuse histiocytosis with intracellular aggregates of basophilic foreign material. Transmission electron microscopy, an underutilized diagnostic test, revealed the nature of the aggregates as heavy metal particles, consistent with lanthanum. Symptoms and histiocytosis improved after discontinuation of lanthanum. Lanthanum may be an underdiagnosed cause of gastrointestinal histiocytosis.

References

  1. BMC Nephrol. 2013 Feb 04;14 :29 - PubMed
  2. Semin Dial. 2008 Mar-Apr;21(2):150-4 - PubMed
  3. Am J Nephrol. 2013;37(1):1-6 - PubMed
  4. Int J Nephrol Renovasc Dis. 2009;2:1-8 - PubMed
  5. Clin Chem. 2012 May;58(5):941-3 - PubMed
  6. Am J Kidney Dis. 2003 Jul;42(1):96-107 - PubMed
  7. Toxicol In Vitro. 2010 Sep;24(6):1743-9 - PubMed
  8. Clin Pharmacokinet. 2008;47(9):553-63 - PubMed
  9. Ann Rheum Dis. 2010 Nov;69(11):2024-33 - PubMed
  10. Histochem J. 1982 Jul;14(4):553-60 - PubMed
  11. J Cell Biol. 1968 Jul;38(1):248-52 - PubMed

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