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Christensen A, Pike CJ. Menopause, obesity and inflammation: interactive risk factors for Alzheimer's disease. Front Aging Neurosci. 2015;7:130doi: 10.3389/fnagi.2015.00130.
Christensen, A., & Pike, C. J. (2015). Menopause, obesity and inflammation: interactive risk factors for Alzheimer's disease. Frontiers in aging neuroscience, 7130. https://doi.org/10.3389/fnagi.2015.00130
Christensen, Amy, and Pike, Christian J. "Menopause, obesity and inflammation: interactive risk factors for Alzheimer's disease." Frontiers in aging neuroscience vol. 7 (2015): 130. doi: https://doi.org/10.3389/fnagi.2015.00130
Christensen A, Pike CJ. Menopause, obesity and inflammation: interactive risk factors for Alzheimer's disease. Front Aging Neurosci. 2015 Jul 07;7:130. doi: 10.3389/fnagi.2015.00130. eCollection 2015. PMID: 26217222; PMCID: PMC4493396.
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Front Aging Neurosci. 2015 Jul 07;7:130. doi: 10.3389/fnagi.2015.00130. eCollection 2015.

Menopause, obesity and inflammation: interactive risk factors for Alzheimer's disease.

Frontiers in aging neuroscience

Amy Christensen, Christian J Pike

Affiliations

  1. Davis School of Gerontology, University of Southern California Los Angeles, CA, USA.

PMID: 26217222 PMCID: PMC4493396 DOI: 10.3389/fnagi.2015.00130

Abstract

Alzheimer's disease (AD) is a multifactorial neurodegenerative disorder, the development of which is regulated by several environmental and genetic risk factors. Two factors theorized to contribute to the initiation and/or progression of AD pathogenesis are age-related increases in inflammation and obesity. These factors may be particularly problematic in women. The onset of menopause in mid-life elevates the vulnerability of women to AD, an increased risk that is likely associated with the depletion of estrogens. Menopause is also linked with an abundance of additional changes, including increased central adiposity and inflammation. Here, we review the current literature to explore the interactions between obesity, inflammation, menopause and AD.

Keywords: Alzheimer’s disease; adiposity; aging; estrogen; hormone therapy; inflammation; obesity

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