Display options
Cite
Vendelova E, Lutz MB, Hrčková G. Immunity and immune modulation elicited by the larval cestode Mesocestoides vogae and its products. Parasite Immunol. 2015;37(10):493-504doi: 10.1111/pim.12216.
Vendelova, E., Lutz, M. B., & Hrčková, G. (2015). Immunity and immune modulation elicited by the larval cestode Mesocestoides vogae and its products. Parasite immunology, 37(10), 493-504. https://doi.org/10.1111/pim.12216
Vendelova, E, et al. "Immunity and immune modulation elicited by the larval cestode Mesocestoides vogae and its products." Parasite immunology vol. 37,10 (2015): 493-504. doi: https://doi.org/10.1111/pim.12216
Vendelova E, Lutz MB, Hrčková G. Immunity and immune modulation elicited by the larval cestode Mesocestoides vogae and its products. Parasite Immunol. 2015 Oct;37(10):493-504. doi: 10.1111/pim.12216. PMID: 26218296.
Copy Download .nbib Format: NLM
Share it on

Parasite Immunol. 2015 Oct;37(10):493-504. doi: 10.1111/pim.12216.

Immunity and immune modulation elicited by the larval cestode Mesocestoides vogae and its products.

Parasite immunology

E Vendelova, M B Lutz, G Hrčková

Affiliations

  1. Institute of Parasitology of the Slovak Academy of Sciences, Košice, Slovak Republic.
  2. Institute of Virology and Immunobiology, University of Wuerzburg, Wuerzburg, Germany.

PMID: 26218296 DOI: 10.1111/pim.12216

Abstract

Larval cestodes (metacestodes) induce long-lasting infections leading to considerable pathology in humans and livestock. Their survival is typically associated with Th2-biased immune responses and immunosuppressive effects and depends on the parasite's ability to excrete/secrete antigens with immunoregulatory properties. Here, Mesocestoides vogae, a natural parasite of mice, is proposed as a new model species for the identification and characterization of cestode-derived immunomodulatory factors. We followed the kinetics of immune parameters after infection with M. vogae or exposure to their excretory/secretory (ES) products in a permissive strain of mice. Besides, a dominant IL-10 production and accumulation of macrophages and eosinophils expressing mRNA for Fizz-1, YM1 and Arg-1, mice showed minimal IFN-γ and transient IL-4 production at early time points with a complete loss at later stages of infection. We found that serum-free ES products without host contamination directly induced M2 macrophages and suppressed IFN-γ production in vivo and in vitro. This study highlights the use of the M. vogae as a cestode infection model and its ES products as a valuable tool for the identification of new therapeutic targets for the control of larval cestodiasis.

© 2015 John Wiley & Sons Ltd.

Keywords: Mesocestoides ; cestodes; excretory-secretory products; immune response; infection

Publication Types