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Koizumi Y, Hiraoka A, Michitaka K, et al. Severe hypoglycemia associated with insulin-like growth factor II-producing liver metastasis from gastric carcinoma treated with overnight total parenteral nutrition via a central vein catheter reserve port. Clin J Gastroenterol. 2011;4(2):68-72doi: 10.1007/s12328-010-0200-y.
Koizumi, Y., Hiraoka, A., Michitaka, K., Tazuya, N., Ichiryu, M., Nakahara, H., Ochi, H., Tanabe, A., Hidaka, S., Kodama, A., Uehara, T., Hasebe, A., Miyamoto, Y., Ninomiya, T., Kumagi, T., Abe, M., Matsuura, B., Horiike, N., Hiasa, Y., & Onji, M. (2011). Severe hypoglycemia associated with insulin-like growth factor II-producing liver metastasis from gastric carcinoma treated with overnight total parenteral nutrition via a central vein catheter reserve port. Clinical journal of gastroenterology, 4(2), 68-72. https://doi.org/10.1007/s12328-010-0200-y
Koizumi, Yohei, et al. "Severe hypoglycemia associated with insulin-like growth factor II-producing liver metastasis from gastric carcinoma treated with overnight total parenteral nutrition via a central vein catheter reserve port." Clinical journal of gastroenterology vol. 4,2 (2011): 68-72. doi: https://doi.org/10.1007/s12328-010-0200-y
Koizumi Y, Hiraoka A, Michitaka K, Tazuya N, Ichiryu M, Nakahara H, Ochi H, Tanabe A, Hidaka S, Kodama A, Uehara T, Hasebe A, Miyamoto Y, Ninomiya T, Kumagi T, Abe M, Matsuura B, Horiike N, Hiasa Y, Onji M. Severe hypoglycemia associated with insulin-like growth factor II-producing liver metastasis from gastric carcinoma treated with overnight total parenteral nutrition via a central vein catheter reserve port. Clin J Gastroenterol. 2011 Apr;4(2):68-72. doi: 10.1007/s12328-010-0200-y. Epub 2011 Jan 21. PMID: 26190708.
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Clin J Gastroenterol. 2011 Apr;4(2):68-72. doi: 10.1007/s12328-010-0200-y. Epub 2011 Jan 21.

Severe hypoglycemia associated with insulin-like growth factor II-producing liver metastasis from gastric carcinoma treated with overnight total parenteral nutrition via a central vein catheter reserve port.

Clinical journal of gastroenterology

Yohei Koizumi, Atsushi Hiraoka, Kojiro Michitaka, Nayu Tazuya, Misa Ichiryu, Hiromasa Nakahara, Hironori Ochi, Atsushi Tanabe, Satoshi Hidaka, Akihiro Kodama, Takahide Uehara, Aki Hasebe, Yasunao Miyamoto, Tomoyuki Ninomiya, Teru Kumagi, Masanori Abe, Bunzo Matsuura, Norio Horiike, Yoichi Hiasa, Morikazu Onji

Affiliations

  1. Department of Gastroenterology, Ehime Prefectural Central Hospital, Ehime, 790-0024, Japan.
  2. Department of Gastroenterology and Metabology, Ehime University Graduate School of Medicine, Shitsukawa, Toon City, Ehime, 791-0295, Japan.
  3. Department of Gastroenterology and Metabology, Ehime University Graduate School of Medicine, Shitsukawa, Toon City, Ehime, 791-0295, Japan. [email protected].

PMID: 26190708 DOI: 10.1007/s12328-010-0200-y

Abstract

Hypoglycemia caused by insulin-like growth factor II is difficult to control. A 77-year-old woman was diagnosed with gastric cancer and multiple liver metastases in September 2006 and underwent chemotherapy; however, at that time there were no symptoms of hypoglycemia. From January 2007 onwards, hypoglycemic comas and symptoms of hypoglycemia began to appear frequently. Her serum level of insulin was normal; thus, we suspected the presence of big insulin-like growth factor II was causing the hypoglycemia. This was proven by Western immunoblotting and we diagnosed non-islet cell tumor hypoglycemia associated with gastric cancer. Overnight nutrition provided via a central venous catheter port to prevent hypoglycemia allowed the patient to become ambulant and to remain free of hypoglycemic coma at follow-up until her death 7 months later.

Keywords: Gastric carcinoma; Hypoglycemia; Insulin-like growth factor (IGF)-II; Non-islet cell tumor hypoglycemia (NICTH)

References

  1. Growth Horm IGF Res. 1998 Jun;8(3):205-10 - PubMed
  2. N Engl J Med. 1988 Dec 1;319(22):1434-40 - PubMed
  3. J Biol Chem. 1996 Jan 5;271(1):203-8 - PubMed
  4. J Clin Endocrinol Metab. 2005 Jul;90(7):3819-23 - PubMed
  5. Intern Med. 2004 Sep;43(9):824-8 - PubMed
  6. Virchows Arch. 1994;424(4):449-52 - PubMed
  7. J Clin Endocrinol Metab. 1995 Sep;80(9):2700-8 - PubMed
  8. Diabetes Metab. 2004 Jun;30(3):276-9 - PubMed
  9. Growth Horm IGF Res. 2006 Aug;16(4):211-6 - PubMed

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