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Meenhuis A, van Vliet R, Hudig F, et al. Successful treatment of a noninhibitory antibody-mediated acquired factor X deficiency in a patient with marginal-zone lymphoma. Clin Case Rep. 2015;3(7):587-93doi: 10.1002/ccr3.294.
Meenhuis, A., van Vliet, R., Hudig, F., Ypma, P. F., Schipperus, M. R., & Hollestelle, M. J. (2015). Successful treatment of a noninhibitory antibody-mediated acquired factor X deficiency in a patient with marginal-zone lymphoma. Clinical case reports, 3(7), 587-93. https://doi.org/10.1002/ccr3.294
Meenhuis, Annemarie, et al. "Successful treatment of a noninhibitory antibody-mediated acquired factor X deficiency in a patient with marginal-zone lymphoma." Clinical case reports vol. 3,7 (2015): 587-93. doi: https://doi.org/10.1002/ccr3.294
Meenhuis A, van Vliet R, Hudig F, Ypma PF, Schipperus MR, Hollestelle MJ. Successful treatment of a noninhibitory antibody-mediated acquired factor X deficiency in a patient with marginal-zone lymphoma. Clin Case Rep. 2015 Jul;3(7):587-93. doi: 10.1002/ccr3.294. Epub 2015 May 25. PMID: 26273448; PMCID: PMC4527802.
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Clin Case Rep. 2015 Jul;3(7):587-93. doi: 10.1002/ccr3.294. Epub 2015 May 25.

Successful treatment of a noninhibitory antibody-mediated acquired factor X deficiency in a patient with marginal-zone lymphoma.

Clinical case reports

Annemarie Meenhuis, Rianne van Vliet, Francisca Hudig, Paula F Ypma, Martin R Schipperus, Martine J Hollestelle

Affiliations

  1. LabWest/ Haga Teaching Hospital The Hague, The Netherlands.
  2. Department of Haematology, Haga Teaching Hospital The Hague, The Netherlands.
  3. Department of Immunopathology and Blood Coagulation, Sanquin Diagnostic Services Amsterdam, The Netherlands.

PMID: 26273448 PMCID: PMC4527802 DOI: 10.1002/ccr3.294

Abstract

Prolonged clotting times were observed in a patient with spontaneous hemorrhage. Analysis showed severe factor X deficiency due to clearance by a noninhibitory antibody. Lymphadenopathy identified on imaging led to diagnosis of marginal B-cell lymphoma. Treatment of lymphoma with rituximab and chlorambucil resulted in complete disappearance of the bleeding disorder.

Keywords: acquired coagulation disorders; clotting factor related research; non-Hodgkin lymphoma

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