Bone Res. 2013 Sep 25;1(3):260-6. doi: 10.4248/BR201303004. eCollection 2013 Sep.
New Clues that May Link Osteoporosis to the Circulating Lipid Profile.
Bone research
Catalina Poiana, Valentin Radoi, Mara Carsote, John P Bilezikian
Affiliations
Affiliations
- "C. I. Parhon" National Institute of Endocrinology, Bucharest , Bucharest, Romania ; University of Medicine and Pharmacy "Carol Davila", Bucharest , Bucharest, Romania.
- University of Medicine and Pharmacy "Carol Davila", Bucharest , Bucharest, Romania.
- College of Physicians and Surgeons, Columbia University , New York, NY USA.
PMID: 26273507
PMCID: PMC4472105 DOI: 10.4248/BR201303004
Abstract
Bone Mineral Density (BMD) is a gold standard for the diagnosis of osteoporosis and is also important in the assessment of fracture risk. Other risk factors have been identified that together make up fracture risk assessment tools such as FRAX. Another potential factor, circulating lipids, has been suggested because of reports linking statins to fracture risk reduction. We analyzed the lipid profile in a cohort of women diagnosed with postmenopausal osteoporosis based on bone density determination: 610 women with osteoporosis (mean lumbar spine T-score -3.16±0.81, mean yrs. since menopause 15.79±8.9) were grouped according to age at evaluation (< 50 years, 51-60 years, 61-70 years, > 70 years), the presence/absence of a history of a fragility fracture, statin and/or antiresorptive drug use. There was no correlation between BMD and Body Mass Index (BMI: P>0.05, r (2)<0.02). However, when BMD was correlated with both BMI and the lipid profile (Triglycerides, Cholesterol, LDLc, HDLc), significant correlations were found in 5 cohorts: 51-60 years with fractures (n=61, r (2)=0.14, P<0.01), 61-70 years (n=201, r (2)=0.09, P<0.01) with fractures (n=88, r (2)=0.14, P<0.01) or without fractures (n=113, r (2)=0.24, P=0.02) and over 70 years (n=247, r (2)=0.11, P<0.01).
Keywords: HDL-cholesterol; bone mineral density; cholesterol; lipid; osteoporosis; triglycerides
References
- J Clin Endocrinol Metab. 2001 Sep;86(9):4556-9 - PubMed
- Bone. 2012 Feb;50(2):525-33 - PubMed
- Curr Pharm Des. 2011 Dec;17(37):4132-46 - PubMed
- Eur J Obstet Gynecol Reprod Biol. 2005 May 1;120(1):63-8 - PubMed
- Lancet. 2000 Jun 24;355(9222):2185-8 - PubMed
- Clin Calcium. 2011 May;21(5):677-82 - PubMed
- Nat Rev Endocrinol. 2011 Sep 06;8(2):81-91 - PubMed
- Bone. 2003 Jan;32(1):8-14 - PubMed
- Bone. 2009 Feb;44(2):208-13 - PubMed
- Ann N Y Acad Sci. 2000 Jun;908:244-54 - PubMed
- Climacteric. 2011 Feb;14 (1):105-11 - PubMed
- Med Hypotheses. 2011 Mar;76(3):317-21 - PubMed
- Pharmacotherapy. 2010 Sep;30(9):879-87 - PubMed
- Bone. 2003 Apr;32(4):427-33 - PubMed
- Ann Intern Med. 2003 Jul 15;139(2):97-104 - PubMed
- Arterioscler Thromb Vasc Biol. 2004 Feb;24(2):e6-10 - PubMed
- Mol Cell Biochem. 2012 Jan;360(1-2):71-7 - PubMed
- Nutr Metab Cardiovasc Dis. 2003 Aug;13(4):227-31 - PubMed
- Endocr J. 2008 Mar;55(1):143-51 - PubMed
- Science. 1999 Dec 3;286(5446):1946-9 - PubMed
- Bone. 2004 Mar;34(3):557-61 - PubMed
- Stroke. 1997 Sep;28(9):1730-2 - PubMed
- Arch Intern Med. 2004 Jan 26;164(2):146-52 - PubMed
- J Bone Miner Res. 2011 Jun;26(6):1197-206 - PubMed
- Cleve Clin J Med. 2002 Apr;69(4):277-8, 280-2, 287-8 - PubMed
- Metabolism. 2004 Jun;53(6):744-8 - PubMed
- Bone. 2010 May;46(5):1226-37 - PubMed
- Am J Med. 2005 Dec;118(12):1414 - PubMed
- Endocr Res. 2003 Aug;29(3):317-25 - PubMed
- Proc Natl Acad Sci U S A. 1999 Jan 5;96(1):133-8 - PubMed
- Eur J Epidemiol. 2004;19(12):1105-12 - PubMed
- Med Hypotheses. 2006;66(5):960-3 - PubMed
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