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Zalonis I, Christidi F, Potagas C, et al. Central Nervous System Involvement as Relapse in Undiagnosed Whipple's Disease with Atypical Symptoms at Onset. Open Neurol J. 2015;9:21-3doi: 10.2174/1874205X01509010021.
Zalonis, I., Christidi, F., Potagas, C., Rentzos, M., Evdokimidis, I., & Kararizou, E. (2015). Central Nervous System Involvement as Relapse in Undiagnosed Whipple's Disease with Atypical Symptoms at Onset. The open neurology journal, 921-3. https://doi.org/10.2174/1874205X01509010021
Zalonis, Ioannis, et al. "Central Nervous System Involvement as Relapse in Undiagnosed Whipple's Disease with Atypical Symptoms at Onset." The open neurology journal vol. 9 (2015): 21-3. doi: https://doi.org/10.2174/1874205X01509010021
Zalonis I, Christidi F, Potagas C, Rentzos M, Evdokimidis I, Kararizou E. Central Nervous System Involvement as Relapse in Undiagnosed Whipple's Disease with Atypical Symptoms at Onset. Open Neurol J. 2015 Jun 26;9:21-3. doi: 10.2174/1874205X01509010021. eCollection 2015. PMID: 26191089; PMCID: PMC4503830.
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Open Neurol J. 2015 Jun 26;9:21-3. doi: 10.2174/1874205X01509010021. eCollection 2015.

Central Nervous System Involvement as Relapse in Undiagnosed Whipple's Disease with Atypical Symptoms at Onset.

The open neurology journal

Ioannis Zalonis, Foteini Christidi, Constantin Potagas, Michalis Rentzos, Ioannis Evdokimidis, Evangelia Kararizou

Affiliations

  1. Department of Neurology, Aeginition Hospital, Medical School, Athens National & Kapodistrian University, 72-74 Vas. Sofias Avenue, Athens, 115 28, Greece.

PMID: 26191089 PMCID: PMC4503830 DOI: 10.2174/1874205X01509010021

Abstract

Whipple's disease (WD) is a rare systemic disease caused by the gram-positive bacillus Tropheryma Whipplei and mostly characterized by arthralgias, chronic diarrhea, weight loss, fever and abdominal pain. Central Nervous System involvement is not uncommon and it may precede other disease manifestations, appear after treatment and improvement of gastrointestinal signs or rarely be the only WD symptom. We report a case in a middle-aged male with unexplained neurological signs and symptoms which were presented as relapse of previously undiagnosed WD with atypical symptoms at onset. After diagnosis confirmation, the patient was appropriately treated which resulted in improvement of major symptoms.

Keywords: Tropheryma whipplei; central nervous system; relapse; whipple’s disease

References

  1. AJNR Am J Neuroradiol. 2010 Sep;31(8):1493-7 - PubMed
  2. Med Mal Infect. 2014 Jul;44(7):331-3 - PubMed
  3. Cogn Behav Neurol. 2010 Mar;23(1):49-51 - PubMed
  4. Clin Endocrinol (Oxf). 1999 Mar;50(3):399-403 - PubMed
  5. J Infect. 2005 Aug;51(2):E35-7 - PubMed
  6. Ann Intern Med. 1981 Jan;94(1):51-2 - PubMed
  7. Gastroenterology. 1985 Jun;88(6):1867-73 - PubMed
  8. Medicine (Baltimore). 2002 Nov;81(6):443-57 - PubMed
  9. Ann Intern Med. 1997 Apr 1;126(7):520-7 - PubMed
  10. Medicine (Baltimore). 1997 May;76(3):170-84 - PubMed
  11. Lancet. 1996 Feb 3;347(8997):329 - PubMed
  12. Clin Neuropathol. 1993 Mar-Apr;12(2):121-4 - PubMed
  13. Electromyogr Clin Neurophysiol. 1995 Mar;35(2):113-6 - PubMed
  14. Medicine (Baltimore). 2013 Nov;92(6):324-30 - PubMed
  15. Ann Neurol. 1996 Oct;40(4):561-8 - PubMed
  16. Mayo Clin Proc. 1988 Jun;63(6):539-51 - PubMed
  17. Brain Behav. 2012 Nov;2(6):838-43 - PubMed
  18. Clin Microbiol Rev. 2001 Jul;14(3):561-83 - PubMed
  19. QJM. 2006 Sep;99(9):609-23 - PubMed

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