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Menke RA, Gray E, Lu CH, et al. CSF neurofilament light chain reflects corticospinal tract degeneration in ALS. Ann Clin Transl Neurol. 2015;2(7):748-55doi: 10.1002/acn3.212.
Menke, R. A., Gray, E., Lu, C. H., Kuhle, J., Talbot, K., Malaspina, A., & Turner, M. R. (2015). CSF neurofilament light chain reflects corticospinal tract degeneration in ALS. Annals of clinical and translational neurology, 2(7), 748-55. https://doi.org/10.1002/acn3.212
Menke, Ricarda A L, et al. "CSF neurofilament light chain reflects corticospinal tract degeneration in ALS." Annals of clinical and translational neurology vol. 2,7 (2015): 748-55. doi: https://doi.org/10.1002/acn3.212
Menke RA, Gray E, Lu CH, Kuhle J, Talbot K, Malaspina A, Turner MR. CSF neurofilament light chain reflects corticospinal tract degeneration in ALS. Ann Clin Transl Neurol. 2015 Jul;2(7):748-55. doi: 10.1002/acn3.212. Epub 2015 May 25. PMID: 26273687; PMCID: PMC4531057.
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Ann Clin Transl Neurol. 2015 Jul;2(7):748-55. doi: 10.1002/acn3.212. Epub 2015 May 25.

CSF neurofilament light chain reflects corticospinal tract degeneration in ALS.

Annals of clinical and translational neurology

Ricarda A L Menke, Elizabeth Gray, Ching-Hua Lu, Jens Kuhle, Kevin Talbot, Andrea Malaspina, Martin R Turner

Affiliations

  1. Nuffield Department of Clinical Neurosciences, University of Oxford Oxford, United Kingdom.
  2. Centre for Neuroscience and Trauma, Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London London, United Kingdom.
  3. Department of Neurology, University Hospital Basel Basel, Switzerland.

PMID: 26273687 PMCID: PMC4531057 DOI: 10.1002/acn3.212

Abstract

OBJECTIVE: Diffusion tensor imaging (DTI) is sensitive to white matter tract pathology. A core signature involving the corticospinal tracts (CSTs) has been identified in amyotrophic lateral sclerosis (ALS). Raised neurofilament light chain protein (NfL) in cerebrospinal fluid (CSF) is thought to reflect axonal damage in a range of neurological disorders. The relationship between these two measures was explored.

METHODS: CSF and serum NfL concentrations and DTI acquired at 3 Tesla on the same day were obtained from ALS patients (n = 25 CSF, 40 serum) and healthy, age-similar controls (n = 17 CSF, 25 serum). Within-group correlations between NfL and DTI measures of microstructural integrity in major white matter tracts (CSTs, superior longitudinal fasciculi [SLF], and corpus callosum) were performed using tract-based spatial statistics.

RESULTS: NfL levels were higher in patients compared to controls. CSF levels correlated with clinical upper motor neuron burden and rate of disease progression. Higher NfL levels were significantly associated with lower DTI fractional anisotropy and increased radial diffusivity in the CSTs of ALS patients, but not in controls.

INTERPRETATION: Elevated CSF and serum NfL is, in part, a result of CST degeneration in ALS. This highlights the wider potential for combining neurochemical and neuroimaging-based biomarkers in neurological disease.

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