Display options
Cite
Jacobson KA, Kirk KL. John W. Daly - An Appreciation. Heterocycles. 2009;79(1):61-71doi: 10.3987/COM-08-S(D)Memoire-1.
Jacobson, K. A., & Kirk, K. L. (2009). John W. Daly - An Appreciation. Heterocycles, 79(1), 61-71. https://doi.org/10.3987/COM-08-S(D)Memoire-1
Jacobson, Kenneth A, and Kirk, Kenneth L. "John W. Daly - An Appreciation." Heterocycles vol. 79,1 (2009): 61-71. doi: https://doi.org/10.3987/COM-08-S(D)Memoire-1
Jacobson KA, Kirk KL. John W. Daly - An Appreciation. Heterocycles. 2009;79(1):61-71. doi: 10.3987/COM-08-S(D)Memoire-1. PMID: 26160996; PMCID: PMC4493916.
Copy Download .nbib Format: NLM
Share it on

Heterocycles. 2009;79(1):61-71. doi: 10.3987/COM-08-S(D)Memoire-1.

John W. Daly - An Appreciation.

Heterocycles

Kenneth A Jacobson, Kenneth L Kirk

Affiliations

  1. Molecular Recognition Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892-0810.

PMID: 26160996 PMCID: PMC4493916 DOI: 10.3987/COM-08-S(D)Memoire-1

Abstract

John W. Daly was engaged in groundbreaking basic research for nearly 50 years at NIH in Bethesda, Maryland. A primary focus of his research included the discovery, structure elucidation, synthesis and pharmacology of alkaloids and other biologically active natural products. However, he earned further acclaim in other areas that included the investigation of the structure-activity relationships for agonists/antagonists at adenosine, adrenergic, histamine, serotonin, and acetylcholine receptors. In addition he was a pioneer in studies of the modulation and functional relationships for systems involving calcium, cyclic nucleotides, ion channels and phospholipids and in the mechanism of actions of caffeine and other xanthines.

References

  1. J Cyclic Nucleotide Res. 1981;7(4):201-24 - PubMed
  2. Science. 1971 Jun 4;172(3987):995-1002 - PubMed
  3. Proc Natl Acad Sci U S A. 1971 Aug;68(8):1870-5 - PubMed
  4. Arch Biochem Biophys. 1959 Aug;83:501-7 - PubMed
  5. J Biol Chem. 1981 Oct 10;256(19):9799-801 - PubMed
  6. J Med Chem. 1985 Apr;28(4):482-6 - PubMed
  7. Mol Interv. 2002 Sep;2(5):276-81 - PubMed
  8. J Biol Chem. 1992 Aug 25;267(24):16834-40 - PubMed
  9. Science. 1965 Nov 12;150(3698):892-3 - PubMed
  10. Science. 1974 Aug 16;185(4151):573-82 - PubMed
  11. Biochem Pharmacol. 2003 Feb 1;65(3):329-38 - PubMed
  12. J Pharmacol Exp Ther. 1977 Jul;202(1):134-43 - PubMed
  13. Science. 1967 Sep 29;157(3796):1524-30 - PubMed
  14. Proc Natl Acad Sci U S A. 1981 Jun;78(6):3363-7 - PubMed
  15. Pharmacol Rev. 1994 Jun;46(2):143-56 - PubMed
  16. Int J Oncol. 2000 May;16(5):971-8 - PubMed
  17. J Med Chem. 1982 Mar;25(3):197-207 - PubMed
  18. Proc Natl Acad Sci U S A. 1997 Dec 23;94(26):14912-7 - PubMed

Publication Types

Grant support