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RSC Adv. 2015;5:28582-28596. doi: 10.1039/C5RA03321G.

Synthesis of Norbornane Bisether Antibiotics via Silver-mediated Alkylation.

RSC advances

Shane M Hickey, Trent D Ashton, Jonathan M White, Jian Li, Roger L Nation, Heidi Y Yu, Alysha G Elliott, Mark S Butler, Johnny X Huang, Matthew A Cooper, Frederick M Pfeffer

Affiliations

  1. Research Centre for Chemistry and Biotechnology, School of Life and Environmental Sciences, Deakin University, Waurn Ponds, Victoria, 3216, Australia.
  2. Bio21 Institute, School of Chemistry, University of Melbourne, Parkville, Victoria, 3010, Australia.
  3. Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Science, Royal Parade, Parkville, Victoria, 3052, Australia.
  4. Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland, 4072, Australia.

PMID: 26251697 PMCID: PMC4523246 DOI: 10.1039/C5RA03321G

Abstract

A small series of norbornane bisether diguanidines have been synthesized and evaluated as antibacterial agents. The key transformation-bisalkylation of norbornane diol

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