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Zanasi A, Cazzato S, Mazzolini M, et al. Does additional antimicrobial treatment have a better effect on URTI cough resolution than homeopathic symptomatic therapy alone? A real-life preliminary observational study in a pediatric population. Multidiscip Respir Med. 2015;10(1):25doi: 10.1186/s40248-015-0022-3.
Zanasi, A., Cazzato, S., Mazzolini, M., Ierna, C. M., Mastroroberto, M., Nardi, E., & Morselli-Labate, A. M. (2015). Does additional antimicrobial treatment have a better effect on URTI cough resolution than homeopathic symptomatic therapy alone? A real-life preliminary observational study in a pediatric population. Multidisciplinary respiratory medicine, 10(1), 25. https://doi.org/10.1186/s40248-015-0022-3
Zanasi, Alessandro, et al. "Does additional antimicrobial treatment have a better effect on URTI cough resolution than homeopathic symptomatic therapy alone? A real-life preliminary observational study in a pediatric population." Multidisciplinary respiratory medicine vol. 10,1 (2015): 25. doi: https://doi.org/10.1186/s40248-015-0022-3
Zanasi A, Cazzato S, Mazzolini M, Ierna CM, Mastroroberto M, Nardi E, Morselli-Labate AM. Does additional antimicrobial treatment have a better effect on URTI cough resolution than homeopathic symptomatic therapy alone? A real-life preliminary observational study in a pediatric population. Multidiscip Respir Med. 2015 Aug 07;10(1):25. doi: 10.1186/s40248-015-0022-3. eCollection 2015. PMID: 26251722; PMCID: PMC4527103.
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Multidiscip Respir Med. 2015 Aug 07;10(1):25. doi: 10.1186/s40248-015-0022-3. eCollection 2015.

Does additional antimicrobial treatment have a better effect on URTI cough resolution than homeopathic symptomatic therapy alone? A real-life preliminary observational study in a pediatric population.

Multidisciplinary respiratory medicine

Alessandro Zanasi, Salvatore Cazzato, Massimiliano Mazzolini, Carla Maria Sofia Ierna, Marianna Mastroroberto, Elena Nardi, Antonio Maria Morselli-Labate

Affiliations

  1. Italian Association for Cough Study (AIST), Via Mazzini, 12, 40138 Bologna, Italy.
  2. Department of Pediatrics, Alma Mater Studiorum - University of Bologna, Bologna, Italy.
  3. Respiratory Medicine and Intensive Care Unit, Sant'Orsola Malpighi Hospital, Alma Mater Studiorum - University of Bologna, Bologna, Italy.
  4. Department of Medical and Surgical Sciences, Alma Mater Studiorum - University of Bologna, Bologna, Italy.

PMID: 26251722 PMCID: PMC4527103 DOI: 10.1186/s40248-015-0022-3

Abstract

BACKGROUND: The effectiveness of a homeopathic syrup on cough has been demonstrated in an adult population in a previous double-blind randomized study. The present prospective observational study investigated children affected by wet acute cough caused by non-complicated URTIs, comparing those who received the homeopathic syrup versus those treated with the homeopathic syrup plus antibiotic.

OBJECTIVES: The aims were: 1) to assess whether the addition of antibiotics to a symptomatic treatment had a role in reducing the severity and duration of acute cough in a pediatric population, as well as in improving cough resolution; 2) to verify the safety of the two treatments.

METHODS: Eighty-five children were enrolled in an open study: 46 children received homeopathic syrup alone for 10 days and 39 children received homeopathic syrup for 10 days plus oral antibiotic treatment (amoxicillin/clavulanate, clarithromycin, and erythromycin) for 7 days. To assess cough severity we used a subjective verbal category-descriptive (VCD) scale.

RESULTS: Cough VCD score was significantly (P < 0.001) reduced in both groups starting from the second day of treatment (-0.52 ± 0.66 in the homeopathic syrup group and -0.56 ± 0.55 in children receiving homeopathic syrup plus oral antibiotic treatment). No significant differences in cough severity or resolution were found between the two groups of children in any of the 28 days of the study. After the first week (day 8) cough was completely resolved in more than one-half of patients in both groups. Two children (4.3 %) reported adverse effects in the group treated with the homeopathic syrup alone, versus 9 children (23.1 %) in the group treated with the homeopathic syrup plus antibiotics (P = 0.020).

CONCLUSIONS: Our data confirm that the homeopathic treatment in question has potential benefits for cough in children as well, and highlight the strong safety profile of this treatment. Additional antibiotic prescription was not associated with a greater cough reduction, and presented more adverse events than the homeopathic syrup alone.

Keywords: Anti-bacterial agents; Antitussive agents; Cough; Homeopathy; Respiratory tract infections

References

  1. Chest. 2013 Dec;144(6):1819-26 - PubMed
  2. Clin Microbiol Infect. 2009 Apr;15 Suppl 3:12-5 - PubMed
  3. Infection. 2004 Apr;32(2):98-108 - PubMed
  4. Pulm Pharmacol Ther. 2014 Feb;27(1):102-8 - PubMed
  5. JAMA. 1998 Mar 18;279(11):875-7 - PubMed
  6. Cochrane Database Syst Rev. 2014 Nov 24;(11):CD001831 - PubMed
  7. Control Clin Trials. 1998 Dec;19(6):589-601 - PubMed
  8. Fam Pract. 2003 Dec;20(6):696-705 - PubMed
  9. Chest. 2011 Mar;139(3):576-80 - PubMed
  10. Cochrane Database Syst Rev. 2000;(2):CD000247 - PubMed
  11. Fam Pract. 2005 Aug;22(4):367-74 - PubMed
  12. JAMA. 2009 Aug 19;302(7):758-66 - PubMed
  13. Eur Respir J. 2002 Oct;20(4):890-8 - PubMed
  14. BMJ. 2013 Dec 11;347:f7027 - PubMed
  15. Cochrane Database Syst Rev. 2013 Jun 04;(6):CD000247 - PubMed
  16. BMC Fam Pract. 2013 Aug 19;14:120 - PubMed
  17. Cough. 2012 Jan 23;8(1):1 - PubMed
  18. Clin Infect Dis. 2008 Mar 15;46(6):815-23 - PubMed
  19. BMC Pediatr. 2011 Jul 05;11:60 - PubMed
  20. Cochrane Database Syst Rev. 2007 Jul 18;(3):CD004417 - PubMed
  21. Am Fam Physician. 2012 Nov 1;86(9):817-22 - PubMed
  22. Cough. 2013 Apr 10;9(1):11 - PubMed
  23. Control Clin Trials. 1990 Apr;11(2):116-28 - PubMed
  24. Pediatrics. 2008 Aug;122(2):e323-9 - PubMed
  25. Scand J Infect Dis. 2002;34(12):880-6 - PubMed
  26. Eur Respir J. 1998 Feb;11(2):462-6 - PubMed

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