Display options
Cite
Khan FA, Al-Jameil N, Khan MF, et al. Thyroid dysfunction: an autoimmune aspect. Int J Clin Exp Med. 2015;8(5):6677-81
Khan, F. A., Al-Jameil, N., Khan, M. F., Al-Rashid, M., & Tabassum, H. (2015). Thyroid dysfunction: an autoimmune aspect. International journal of clinical and experimental medicine, 8(5), 6677-81.
Khan, Farah Aziz, et al. "Thyroid dysfunction: an autoimmune aspect." International journal of clinical and experimental medicine vol. 8,5 (2015): 6677-81.
Khan FA, Al-Jameil N, Khan MF, Al-Rashid M, Tabassum H. Thyroid dysfunction: an autoimmune aspect. Int J Clin Exp Med. 2015 May 15;8(5):6677-81. eCollection 2015. PMID: 26221205; PMCID: PMC4509150.
Copy Download .nbib Format: NLM
Share it on

Int J Clin Exp Med. 2015 May 15;8(5):6677-81. eCollection 2015.

Thyroid dysfunction: an autoimmune aspect.

International journal of clinical and experimental medicine

Farah Aziz Khan, Noura Al-Jameil, Mohammad Fareed Khan, May Al-Rashid, Hajera Tabassum

Affiliations

  1. Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, King Saud University Riyadh, K.S.A.

PMID: 26221205 PMCID: PMC4509150

Abstract

Auto immune thyroid disease (AITD) is the common organ specific autoimmune disorder, Hashimoto thyroiditis (HT) and Grave's disease (GD) are its well-known sequelae. It occurs due to loss of tolerance to autoantigens thyroid peroxidase (TPO), thyroglobulin (Tg), thyroid stimulating hormone receptor (TSH-R) which leads to the infiltration of the gland. T cells in chronic autoimmune thyroiditis (cAIT) induce apoptosis in thyroid follicular cells and cause destruction of the gland. Presences of TPO antibodies are common in HT and GD, while Tg has been reported as an independent predictor of thyroid malignancy. Cytokines are small proteins play an important role in autoimmunity, by stimulating B and T cells. Various cytokines IL-1α, IL-1β, IL-2, IL-4, IL-6, IL-8, IL-10, IL-12, IL-13, IL-14, TNF-α and IFN-γ are found in thyroid follicular cells which enhance inflammatory response with nitric oxide (NO) and prostaglandins.

Keywords: Autoimmunity; antibody; cytokines; lymphocytes; thyroglobulin; thyroid peroxidase

References

  1. Endocr Rev. 1992 May;13(2):192-206 - PubMed
  2. Eur J Endocrinol. 2003 Jan;148(1):1-9 - PubMed
  3. Thyroid. 2008 Sep;18(9):953-8 - PubMed
  4. J Endocrinol. 2005 Oct;187(1):1-15 - PubMed
  5. Clin Exp Immunol. 2002 Jan;127(1):99-106 - PubMed
  6. Ann Surg Oncol. 2014 Aug;21(8):2725-32 - PubMed
  7. J Interferon Cytokine Res. 2011 Oct;31(10):721-31 - PubMed
  8. J Autoimmun. 2008 Feb-Mar;30(1-2):58-62 - PubMed
  9. Neuroimmunomodulation. 2011;18(1):45-51 - PubMed
  10. Nat Clin Pract Endocrinol Metab. 2008 Jul;4(7):394-405 - PubMed
  11. Adv Neuroimmunol. 1996;6(4):359-86 - PubMed
  12. Annu Rev Immunol. 2000;18:423-49 - PubMed
  13. J Clin Endocrinol Metab. 2000 May;85(5):1984-8 - PubMed
  14. Eur J Nucl Med Mol Imaging. 2002 Aug;29 Suppl 2:S417-24 - PubMed
  15. J Clin Endocrinol Metab. 2002 Feb;87(2):489-99 - PubMed
  16. Thyroid. 2007 Oct;17(10):975-9 - PubMed
  17. Clin Endocrinol (Oxf). 2013 Jan;78(1):1-8 - PubMed
  18. Trends Immunol. 2004 Apr;25(4):210-7 - PubMed
  19. Curr Drug Targets Immune Endocr Metabol Disord. 2004 Dec;4(4):343-61 - PubMed
  20. Nature. 2007 Jul 26;448(7152):484-7 - PubMed
  21. Lancet. 2012 Mar 24;379(9821):1142-54 - PubMed
  22. Autoimmunity. 1997;26(2):129-36 - PubMed
  23. Nat Immunol. 2000 Sep;1(3):199-205 - PubMed
  24. Endokrynol Pol. 2014;65(2):150-5 - PubMed
  25. Clin Endocrinol (Oxf). 1995 Jul;43(1):55-68 - PubMed
  26. Eur J Immunol. 1999 Mar;29(3):958-63 - PubMed
  27. Immunity. 2006 Jun;24(6):677-88 - PubMed
  28. Cell. 2008 May 30;133(5):775-87 - PubMed
  29. Ann N Y Acad Sci. 2002 Jun;966:496-501 - PubMed
  30. J Thyroid Res. 2013;2013:542692 - PubMed
  31. Autoimmunity. 2003 Sep-Nov;36(6-7):323-30 - PubMed
  32. J Clin Endocrinol Metab. 1991 Aug;73(2):421-7 - PubMed
  33. Best Pract Res Clin Endocrinol Metab. 2004 Jun;18(2):167-81 - PubMed
  34. Eur J Endocrinol. 2004 Jun;150(6):751-5 - PubMed
  35. Endocrinology. 2009 Nov;150(11):5135-42 - PubMed
  36. Thyroid. 2009 May;19(5):495-501 - PubMed
  37. Eur J Immunol. 2004 Jan;34(1):263-72 - PubMed
  38. J Clin Endocrinol Metab. 2010 Feb;95(2):953-62 - PubMed
  39. Dan Med Bull. 2000 Apr;47(2):94-114 - PubMed
  40. Horm Res. 2003;59(3):118-24 - PubMed
  41. Immunol Today. 1997 Sep;18(9):437-42 - PubMed
  42. Clin Endocrinol (Oxf). 1977 Dec;7(6):481-93 - PubMed
  43. JAMA. 1990 Sep 19;264(11):1422-5 - PubMed
  44. Thyroid. 2007 Oct;17(10):981-8 - PubMed

Publication Types