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Sumida T, Kitadai Y, Masuda H, et al. Rapid progression of Epstein-Barr-virus-positive gastric diffuse large B-cell lymphoma during chemoradiotherapy: a case report. Clin J Gastroenterol. 2008;1(3):105-109doi: 10.1007/s12328-008-0020-5.
Sumida, T., Kitadai, Y., Masuda, H., Shinagawa, K., Tanaka, M., Kodama, M., Kuroda, T., Hiyama, T., Tanaka, S., Nakayama, H., Yoshihara, M., Yoshino, T., & Chayama, K. (2008). Rapid progression of Epstein-Barr-virus-positive gastric diffuse large B-cell lymphoma during chemoradiotherapy: a case report. Clinical journal of gastroenterology, 1(3), 105-109. https://doi.org/10.1007/s12328-008-0020-5
Sumida, Tomonori, et al. "Rapid progression of Epstein-Barr-virus-positive gastric diffuse large B-cell lymphoma during chemoradiotherapy: a case report." Clinical journal of gastroenterology vol. 1,3 (2008): 105-109. doi: https://doi.org/10.1007/s12328-008-0020-5
Sumida T, Kitadai Y, Masuda H, Shinagawa K, Tanaka M, Kodama M, Kuroda T, Hiyama T, Tanaka S, Nakayama H, Yoshihara M, Yoshino T, Chayama K. Rapid progression of Epstein-Barr-virus-positive gastric diffuse large B-cell lymphoma during chemoradiotherapy: a case report. Clin J Gastroenterol. 2008 Oct;1(3):105-109. doi: 10.1007/s12328-008-0020-5. Epub 2008 Aug 12. PMID: 26193647.
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Clin J Gastroenterol. 2008 Oct;1(3):105-109. doi: 10.1007/s12328-008-0020-5. Epub 2008 Aug 12.

Rapid progression of Epstein-Barr-virus-positive gastric diffuse large B-cell lymphoma during chemoradiotherapy: a case report.

Clinical journal of gastroenterology

Tomonori Sumida, Yasuhiko Kitadai, Hiroshi Masuda, Kei Shinagawa, Miwako Tanaka, Michiyo Kodama, Tsuyoshi Kuroda, Toru Hiyama, Shinji Tanaka, Hirofumi Nakayama, Masaharu Yoshihara, Tadashi Yoshino, Kazuaki Chayama

Affiliations

  1. Department of Medicine and Molecular Science, Hiroshima University Graduate School of Biomedical Science, 1-2-3 Kasumi, Minami-ku, Hiroshima, 734-8551, Japan.
  2. Department of Medicine and Molecular Science, Hiroshima University Graduate School of Biomedical Science, 1-2-3 Kasumi, Minami-ku, Hiroshima, 734-8551, Japan. [email protected].
  3. Health Service Center, Hiroshima University, Hiroshima, Japan.
  4. Department of Endoscopy, Hiroshima University Hospital, Hiroshima, Japan.
  5. Department of Pathology, Hiroshima University Graduate School of Biomedical Science, Hiroshima, Japan.
  6. Department of Pathology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Science, Okayama, Japan.

PMID: 26193647 DOI: 10.1007/s12328-008-0020-5

Abstract

A 61-year-old woman was referred to our hospital with epigastralgia and appetite loss. Barium examination and upper gastrointestinal endoscopy revealed uneven erythematous mucosa with multiple elevated lesions from the gastric fornix to the upper corpus. Abdominal computed tomography showed thickening of the wall of the fornix and swelling of perigastric lymph nodes, but whole-body gallium scintigraphy and bone marrow examination did not indicate further involvement. Biopsy specimens showed diffuse infiltration of large atypical lymphoid cells in which Epstein-Barr virus (EBV) was detected by in situ hybridization. Diffuse large B-cell lymphoma (DLBCL), stage II1, was diagnosed. Combination chemotherapy [cyclophosphamide, adriamycin, vincristine, and prednisone (CHOP)], was given, and this was followed by radiotherapy. Partial remission was achieved by chemotherapy, but the disease progressed rapidly during radiotherapy. Because the reported prognosis of EBV-positive DLBCL is unfavorable, the therapeutic strategy for EBV-positive gastric DLBCL should be considered carefully.

Keywords: Chemoradiotherapy; Diffuse large B-cell lymphoma; Epstein-Barr virus

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