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Kumagi T, Heathcote EJ. Successfully treated intractable pruritus with rifampin in a case of benign recurrent intrahepatic cholestasis. Clin J Gastroenterol. 2008;1(4):160-163doi: 10.1007/s12328-008-0027-y.
Kumagi, T., & Heathcote, E. J. (2008). Successfully treated intractable pruritus with rifampin in a case of benign recurrent intrahepatic cholestasis. Clinical journal of gastroenterology, 1(4), 160-163. https://doi.org/10.1007/s12328-008-0027-y
Kumagi, Teru, and Heathcote, E Jenny. "Successfully treated intractable pruritus with rifampin in a case of benign recurrent intrahepatic cholestasis." Clinical journal of gastroenterology vol. 1,4 (2008): 160-163. doi: https://doi.org/10.1007/s12328-008-0027-y
Kumagi T, Heathcote EJ. Successfully treated intractable pruritus with rifampin in a case of benign recurrent intrahepatic cholestasis. Clin J Gastroenterol. 2008 Dec;1(4):160-163. doi: 10.1007/s12328-008-0027-y. Epub 2008 Sep 26. PMID: 26193696.
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Clin J Gastroenterol. 2008 Dec;1(4):160-163. doi: 10.1007/s12328-008-0027-y. Epub 2008 Sep 26.

Successfully treated intractable pruritus with rifampin in a case of benign recurrent intrahepatic cholestasis.

Clinical journal of gastroenterology

Teru Kumagi, E Jenny Heathcote

Affiliations

  1. Department of Medicine, Toronto Western Hospital (University Health Network/University of Toronto), 399 Bathurst St., Toronto, ON, M5T2S8, Canada.
  2. Department of Medicine, Toronto Western Hospital (University Health Network/University of Toronto), 399 Bathurst St., Toronto, ON, M5T2S8, Canada. [email protected].

PMID: 26193696 DOI: 10.1007/s12328-008-0027-y

Abstract

A 56-year-old gentleman with benign recurrent intrahepatic cholestasis (BRIC) suffered from recurrent episodes of pruritus for over 40 years. The treatment prescribed, namely cholestyramine, was minimally effective. However, rifampin 150 mg b.i.d promptly and completely relieved his severe pruritus. The diagnosis of BRIC, being a rare condition, may go unrecognized. The severity of the lifelong episodes of intermittent cholestasis with pruritus in BRIC may be extremely distressing to the affected patient. Administration of rifampin during the acute episode of severe pruritus led to a marked improvement in his quality of life.

Keywords: Benign recurrent intrahepatic cholestasis (BRIC); Pruritus; Rifampin

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