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Robuccio A, Ssentongo P, Sather MD, et al. Intractable myoclonic seizures in an allogeneic stem cell transplant recipient: A rare case of myoclonic epilepsy. Epilepsy Behav Case Rep. 2015;4:48-51doi: 10.1016/j.ebcr.2015.06.005.
Robuccio, A., Ssentongo, P., Sather, M. D., Claxton, D. F., & Gilliam, F. G. (2015). Intractable myoclonic seizures in an allogeneic stem cell transplant recipient: A rare case of myoclonic epilepsy. Epilepsy & behavior case reports, 448-51. https://doi.org/10.1016/j.ebcr.2015.06.005
Robuccio, Anna, et al. "Intractable myoclonic seizures in an allogeneic stem cell transplant recipient: A rare case of myoclonic epilepsy." Epilepsy & behavior case reports vol. 4 (2015): 48-51. doi: https://doi.org/10.1016/j.ebcr.2015.06.005
Robuccio A, Ssentongo P, Sather MD, Claxton DF, Gilliam FG. Intractable myoclonic seizures in an allogeneic stem cell transplant recipient: A rare case of myoclonic epilepsy. Epilepsy Behav Case Rep. 2015 Aug 08;4:48-51. doi: 10.1016/j.ebcr.2015.06.005. eCollection 2015. PMID: 26288756; PMCID: PMC4536288.
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Epilepsy Behav Case Rep. 2015 Aug 08;4:48-51. doi: 10.1016/j.ebcr.2015.06.005. eCollection 2015.

Intractable myoclonic seizures in an allogeneic stem cell transplant recipient: A rare case of myoclonic epilepsy.

Epilepsy & behavior case reports

Anna Robuccio, Paddy Ssentongo, Michael D Sather, David F Claxton, Frank G Gilliam

Affiliations

  1. Center for Neural Engineering, Science and Mechanics, The Pennsylvania State University, University Park, PA 16802, USA ; Department of Engineering, Science and Mechanics, The Pennsylvania State University, University Park, PA 16802, USA.
  2. Department of Neurosurgery, Penn State Hershey College of Medicine, 500 University Drive, Hershey, PA 17033, USA.
  3. Penn State Cancer Institute, Penn State Hershey College of Medicine, 500 University Drive, Hershey, PA 17033, USA.
  4. Center for Neural Engineering, Science and Mechanics, The Pennsylvania State University, University Park, PA 16802, USA ; Department of Neurology, Penn State Hershey College of Medicine, 500 University Drive, Hershey, PA 17033, USA ; Department of Neurosurgery, Penn State Hershey College of Medicine, 500 University Drive, Hershey, PA 17033, USA.

PMID: 26288756 PMCID: PMC4536288 DOI: 10.1016/j.ebcr.2015.06.005

Abstract

INTRODUCTION: Myoclonus may be a rare complication of stem cell transplant but has limited discussion in the scientific literature.

CASE: We present a case of an acute myeloid leukemia survivor who developed refractory myoclonic epilepsy four years after graft versus host disease (GVHD) developed six days following matched unrelated allogeneic hematopoietic stem cell transplant.

DISCUSSION: Graft versus host disease occurs in 30-50% of allogenic hematopoietic stem cell transplant patients and may cause pharmacoresistant myoclonic epilepsy; however, the mechanisms by which GVHD leads to recurrent myoclonic seizures are not well understood (Lee, 2005) [1]. The paucity of clinical reports of such manifestation makes it difficult to diagnose and effectively manage these patients.

Keywords: Allogeneic transplants; Epilepsy; GVHD; Myoclonus; Seizure

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