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Zhou B, Blanchard A, Wang N, et al. Claudin 1 Promotes Migration and Increases Sensitivity to Tamoxifen and Anticancer Drugs in Luminal-like Human Breast Cancer Cells MCF7. Cancer Invest. 2015;
Zhou, B., Blanchard, A., Wang, N., Ma, X., Han, J., Schroedter, I., Leygue, E., & Myal, Y. (2015). Claudin 1 Promotes Migration and Increases Sensitivity to Tamoxifen and Anticancer Drugs in Luminal-like Human Breast Cancer Cells MCF7. Cancer investigation, .
Zhou, Bowen, et al. "Claudin 1 Promotes Migration and Increases Sensitivity to Tamoxifen and Anticancer Drugs in Luminal-like Human Breast Cancer Cells MCF7." Cancer investigation vol. (2015).
Zhou B, Blanchard A, Wang N, Ma X, Han J, Schroedter I, Leygue E, Myal Y. Claudin 1 Promotes Migration and Increases Sensitivity to Tamoxifen and Anticancer Drugs in Luminal-like Human Breast Cancer Cells MCF7. Cancer Invest. 2015 Aug 17; Epub 2015 Aug 17. PMID: 26279089.
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Cancer Invest. 2015 Aug 17; Epub 2015 Aug 17.

Claudin 1 Promotes Migration and Increases Sensitivity to Tamoxifen and Anticancer Drugs in Luminal-like Human Breast Cancer Cells MCF7.

Cancer investigation

Bowen Zhou, Anne Blanchard, Nan Wang, Xiuli Ma, Jihyun Han, Ingo Schroedter, Etienne Leygue, Yvonne Myal

Affiliations

  1. 1Faculty of Health Sciences, Department of Pathology, College of Medicine, University of Manitoba , Winnipeg , Canada.

PMID: 26279089

Abstract

Downregulation of claudin 1, a critical tight junction protein, has been correlated with increased invasiveness in breast cancer. However, recent studies suggest that claudin 1 contributes to the progression of some molecular subtypes of breast cancer. In this study, claudin 1 promotes migration in luminal-like MCF7 human breast cancer cells and increases their sensitivity to tamoxifen, etoposide, and cisplatin. We also observed an inverse relationship between upregulation of claudin 1 and TGFβ. Collectively, our results suggest that claudin 1 has the potential to be used as a predictive marker for treatment efficacy for specific breast cancer patient subgroups.

Keywords: Breast cancer; Claudin 1; Estrogen; MCF7; Migration; TGFβ; Tamoxifen

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