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Ainsztein AM, Brooks PJ, Dugan VG, et al. The NIH Extracellular RNA Communication Consortium. J Extracell Vesicles. 2015;4:27493doi: 10.3402/jev.v4.27493.
Ainsztein, A. M., Brooks, P. J., Dugan, V. G., Ganguly, A., Guo, M., Howcroft, T. K., Kelley, C. A., Kuo, L. S., Labosky, P. A., Lenzi, R., McKie, G. A., Mohla, S., Procaccini, D., Reilly, M., Satterlee, J. S., Srinivas, P. R., Church, E. S., Sutherland, M., Tagle, D. A., Tucker, J. M., & Venkatachalam, S. (2015). The NIH Extracellular RNA Communication Consortium. Journal of extracellular vesicles, 427493. https://doi.org/10.3402/jev.v4.27493
Ainsztein, Alexandra M, et al. "The NIH Extracellular RNA Communication Consortium." Journal of extracellular vesicles vol. 4 (2015): 27493. doi: https://doi.org/10.3402/jev.v4.27493
Ainsztein AM, Brooks PJ, Dugan VG, Ganguly A, Guo M, Howcroft TK, Kelley CA, Kuo LS, Labosky PA, Lenzi R, McKie GA, Mohla S, Procaccini D, Reilly M, Satterlee JS, Srinivas PR, Church ES, Sutherland M, Tagle DA, Tucker JM, Venkatachalam S. The NIH Extracellular RNA Communication Consortium. J Extracell Vesicles. 2015 Aug 28;4:27493. doi: 10.3402/jev.v4.27493. eCollection 2015. PMID: 26320938; PMCID: PMC4553264.
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J Extracell Vesicles. 2015 Aug 28;4:27493. doi: 10.3402/jev.v4.27493. eCollection 2015.

The NIH Extracellular RNA Communication Consortium.

Journal of extracellular vesicles

Alexandra M Ainsztein, Philip J Brooks, Vivien G Dugan, Aniruddha Ganguly, Max Guo, T Kevin Howcroft, Christine A Kelley, Lillian S Kuo, Patricia A Labosky, Rebecca Lenzi, George A McKie, Suresh Mohla, Dena Procaccini, Matthew Reilly, John S Satterlee, Pothur R Srinivas, Elizabeth Stansell Church, Margaret Sutherland, Danilo A Tagle, Jessica M Tucker, Sundar Venkatachalam

Affiliations

  1. Division of Cell Biology and Biophysics, National Institute of General Medical Sciences (NIGMS), Bethesda, MD, USA.
  2. Division of Clinical Innovation, National Center for Advancing Translational Sciences (NCATS), Bethesda, MD, USA.
  3. Office of Genomics and Advanced Technologies, Division of Microbiology and Infectious Diseases, National Institute of Allergy and Infectious Diseases (NIAID), Rockville, MD, USA.
  4. Cancer Diagnosis Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute (NCI), Rockville, MD, USA.
  5. Genetics and Cell Biology Branch, Division of Aging Biology, National Institute on Aging (NIA), Bethesda, MD, USA.
  6. Division of Cancer Biology, Cancer Immunology, Hematology, and Etiology Branch, National Cancer Institute (NCI), Rockville, MD, USA; [email protected].
  7. Division of Discovery Science and Technology, National Institute of Biomedical Imaging and Bioengineering (NIBIB), Bethesda, MD, USA.
  8. National Center for Advancing Translational Science (NCATS), Bethesda, MD, USA.
  9. Office of Strategic Coordination, Division of Program Coordination, Planning, and Strategic Initiatives (DPCPSI), National Institutes of Health (NIH), Bethesda, MD, USA.
  10. Ocular Infection, Inflammation, and Immunology, National Eye Institute (NEI), Rockville, MD, USA.
  11. Division of Cancer Biology, Tumor Biology and Metastasis Branch (TBMB), National Cancer Institute (NCI), Rockville, MD, USA.
  12. National Institute on Drug Abuse (NIDA), Rockville, MD, USA.
  13. Division of Neuroscience & Behavior, National Institute on Alcohol Abuse and Alcoholism (NIAAA), Rockville, MD, USA.
  14. Division of Cardiovascular Sciences, National Heart, Lung, and Blood Institute (NHLBI), Bethesda, MD, USA.
  15. Pathogenesis and Basic Research Branch, Division of AIDS, National Institute of Allergy and Infectious Diseases (NIAID), Rockville, MD, USA.
  16. Neurodegeneration Cluster, National Institute of Neurological Disorders and Stroke (NINDS), Rockville, MD, USA.
  17. National Institute of Biomedical Imaging and Bioengineering (NIBIB), Bethesda, MD, USA.
  18. Integrative Biology and Infectious Diseases Branch, National Institute of Dental and Craniofacial Research (NIDCR), Bethesda, MD, USA.

PMID: 26320938 PMCID: PMC4553264 DOI: 10.3402/jev.v4.27493

Abstract

The Extracellular RNA (exRNA) Communication Consortium, funded as an initiative of the NIH Common Fund, represents a consortium of investigators assembled to address the critical issues in the exRNA research arena. The overarching goal is to generate a multi-component community resource for sharing fundamental scientific discoveries, protocols, and innovative tools and technologies. The key initiatives include (a) generating a reference catalogue of exRNAs present in body fluids of normal healthy individuals that would facilitate disease diagnosis and therapies, (b) defining the fundamental principles of exRNA biogenesis, distribution, uptake, and function, as well as development of molecular tools, technologies, and imaging modalities to enable these studies,

(c) identifying exRNA biomarkers of disease, (d) demonstrating clinical utility of exRNAs as therapeutic agents and developing scalable technologies required for these studies, and (e) developing a community resource, the exRNA Atlas, to provide the scientific community access to exRNA data, standardized exRNA protocols, and other useful tools and technologies generated by funded investigators.

Keywords: ERCC; exRNA; extracellular RNA

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