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Yuan Y, Seong E, Yuan L, et al. Differential regulation of apical-basolateral dendrite outgrowth by activity in hippocampal neurons. Front Cell Neurosci. 2015;9:314doi: 10.3389/fncel.2015.00314.
Yuan, Y., Seong, E., Yuan, L., Singh, D., & Arikkath, J. (2015). Differential regulation of apical-basolateral dendrite outgrowth by activity in hippocampal neurons. Frontiers in cellular neuroscience, 9314. https://doi.org/10.3389/fncel.2015.00314
Yuan, Yang, et al. "Differential regulation of apical-basolateral dendrite outgrowth by activity in hippocampal neurons." Frontiers in cellular neuroscience vol. 9 (2015): 314. doi: https://doi.org/10.3389/fncel.2015.00314
Yuan Y, Seong E, Yuan L, Singh D, Arikkath J. Differential regulation of apical-basolateral dendrite outgrowth by activity in hippocampal neurons. Front Cell Neurosci. 2015 Aug 11;9:314. doi: 10.3389/fncel.2015.00314. eCollection 2015. PMID: 26321915; PMCID: PMC4531327.
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Front Cell Neurosci. 2015 Aug 11;9:314. doi: 10.3389/fncel.2015.00314. eCollection 2015.

Differential regulation of apical-basolateral dendrite outgrowth by activity in hippocampal neurons.

Frontiers in cellular neuroscience

Yang Yuan, Eunju Seong, Li Yuan, Dipika Singh, Jyothi Arikkath

Affiliations

  1. Developmental Neuroscience, Munroe-Meyer Institute, University of Nebraska Medical Center, Omaha, NE USA.
  2. Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE USA.
  3. Developmental Neuroscience, Munroe-Meyer Institute, University of Nebraska Medical Center, Omaha, NE USA ; Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE USA.

PMID: 26321915 PMCID: PMC4531327 DOI: 10.3389/fncel.2015.00314

Abstract

Hippocampal pyramidal neurons have characteristic dendrite asymmetry, characterized by structurally and functionally distinct apical and basolateral dendrites. The ability of the neuron to generate and maintain dendrite asymmetry is vital, since synaptic inputs received are critically dependent on dendrite architecture. Little is known about the role of neuronal activity in guiding maintenance of dendrite asymmetry. Our data indicate that dendrite asymmetry is established and maintained early during development. Further, our results indicate that cell intrinsic and global alterations of neuronal activity have differential effects on net extension of apical and basolateral dendrites. Thus, apical and basolateral dendrite extension may be independently regulated by cell intrinsic and network neuronal activity during development, suggesting that individual dendrites may have autonomous control over net extension. We propose that regulated individual dendrite extension in response to cell intrinsic and neuronal network activity may allow temporal control of synapse specificity in the developing hippocampus.

Keywords: apical–basolateral; dendrite; neuronal plasticity; pyramidal neuron; synapse development

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