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Akbar SR, Long DM, Hussain K, et al. Hyperuricemia: An Early Marker for Severity of Illness in Sepsis. Int J Nephrol. 2015;2015:301021doi: 10.1155/2015/301021.
Akbar, S. R., Long, D. M., Hussain, K., Alhajhusain, A., Ahmed, U. S., Iqbal, H. I., Ali, A. W., Leonard, R., & Dalton, C. (2015). Hyperuricemia: An Early Marker for Severity of Illness in Sepsis. International journal of nephrology, 2015301021. https://doi.org/10.1155/2015/301021
Akbar, Sana R, et al. "Hyperuricemia: An Early Marker for Severity of Illness in Sepsis." International journal of nephrology vol. 2015 (2015): 301021. doi: https://doi.org/10.1155/2015/301021
Akbar SR, Long DM, Hussain K, Alhajhusain A, Ahmed US, Iqbal HI, Ali AW, Leonard R, Dalton C. Hyperuricemia: An Early Marker for Severity of Illness in Sepsis. Int J Nephrol. 2015;2015:301021. doi: 10.1155/2015/301021. Epub 2015 Jul 29. PMID: 26294973; PMCID: PMC4532866.
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Int J Nephrol. 2015;2015:301021. doi: 10.1155/2015/301021. Epub 2015 Jul 29.

Hyperuricemia: An Early Marker for Severity of Illness in Sepsis.

International journal of nephrology

Sana R Akbar, Dustin M Long, Kashif Hussain, Ahmad Alhajhusain, Umair S Ahmed, Hafiz I Iqbal, Ailia W Ali, Rachel Leonard, Cheryl Dalton

Affiliations

  1. Division of Nephrology, Department of Medicine, West Virginia University School of Medicine, Morgantown, WV, USA.
  2. Division of Biostatistics, West Virginia University School of Medicine, Morgantown, WV, USA.
  3. Division of Pulmonary and Critical Care Medicine, Department of Medicine, West Virginia University School of Medicine, Morgantown, WV, USA.
  4. Department of Medicine, West Virginia University School of Medicine, Morgantown, WV, USA.

PMID: 26294973 PMCID: PMC4532866 DOI: 10.1155/2015/301021

Abstract

Background. Uric acid can acutely activate various inflammatory transcription factors. Since high levels of oxyradicals and lower antioxidant levels in septic patients are believed to result in multiorgan failure, uric acid levels could be used as a marker of oxidative stress and poor prognosis in patients with sepsis. Design. We conducted a prospective cohort study on Medical Intensive Care Unit (MICU) patients and hypothesized that elevated uric acid in patients with sepsis is predictive of greater morbidity. The primary end point was the correlation between hyperuricemia and the morbidity rate. Secondary end points were Acute Kidney Injury (AKI), mortality, Acute Respiratory Distress Syndrome (ARDS), and duration of stay. Results. We enrolled 144 patients. 54 (37.5%) had the primary end point of hyperuricemia. The overall morbidity rate was 85.2%. The probability of having hyperuricemia along with AKI was 68.5% and without AKI was 31.5%. Meanwhile the probability of having a uric acid value <7 mg/dL along with AKI was 18.9% and without AKI was 81.1% (p value < 0.0001). Conclusion. We report that elevated uric acid levels on arrival to the MICU in patients with sepsis are associated with poor prognosis. These patients are at an increased risk for AKI and ARDS.

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