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Wachowska M, Muchowicz A, Golab J. Targeting Epigenetic Processes in Photodynamic Therapy-Induced Anticancer Immunity. Front Oncol. 2015;5:176doi: 10.3389/fonc.2015.00176.
Wachowska, M., Muchowicz, A., & Golab, J. (2015). Targeting Epigenetic Processes in Photodynamic Therapy-Induced Anticancer Immunity. Frontiers in oncology, 5176. https://doi.org/10.3389/fonc.2015.00176
Wachowska, Malgorzata, et al. "Targeting Epigenetic Processes in Photodynamic Therapy-Induced Anticancer Immunity." Frontiers in oncology vol. 5 (2015): 176. doi: https://doi.org/10.3389/fonc.2015.00176
Wachowska M, Muchowicz A, Golab J. Targeting Epigenetic Processes in Photodynamic Therapy-Induced Anticancer Immunity. Front Oncol. 2015 Jul 30;5:176. doi: 10.3389/fonc.2015.00176. eCollection 2015. PMID: 26284197; PMCID: PMC4519687.
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Front Oncol. 2015 Jul 30;5:176. doi: 10.3389/fonc.2015.00176. eCollection 2015.

Targeting Epigenetic Processes in Photodynamic Therapy-Induced Anticancer Immunity.

Frontiers in oncology

Malgorzata Wachowska, Angelika Muchowicz, Jakub Golab

Affiliations

  1. Department of Immunology, Medical University of Warsaw , Warsaw , Poland.

PMID: 26284197 PMCID: PMC4519687 DOI: 10.3389/fonc.2015.00176

Abstract

Photodynamic therapy (PDT) of cancer is an approved therapeutic procedure that generates oxidative stress leading to cell death of tumor and stromal cells. Cell death resulting from oxidative damage to intracellular components leads to the release of damage-associated molecular patterns (DAMPs) that trigger robust inflammatory response and creates local conditions for effective sampling of tumor-associated antigens (TAA) by antigen-presenting cells. The latter can trigger development of TAA-specific adaptive immune response. However, due to a number of mechanisms, including epigenetic regulation of TAA expression, tumor cells evade immune recognition. Therefore, numerous approaches are being developed to combine PDT with immunotherapies to allow development of systemic immunity. In this review, we describe immunoregulatory mechanisms of epigenetic treatments that were shown to restore the expression of epigenetically silenced or down-regulated major histocompatibility complex molecules as well as TAA. We also discuss the results of our recent studies showing that epigenetic treatments based on administration of methyltransferase inhibitors in combination with PDT can release effective mechanisms leading to development of antitumor immunity and potentiated antitumor effects.

Keywords: cancer; epigenetic mechanisms; histone deacetylase; immunotherapy; methyltransferase; photodynamic therapy

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