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Giordano C, Rivas J, Zervos X. An Update on Treatment of Drug-Induced Liver Injury. J Clin Transl Hepatol. 2014;2(2):74-9doi: 10.14218/JCTH.2014.00005.
Giordano, C., Rivas, J., & Zervos, X. (2014). An Update on Treatment of Drug-Induced Liver Injury. Journal of clinical and translational hepatology, 2(2), 74-9. https://doi.org/10.14218/JCTH.2014.00005
Giordano, Christin, et al. "An Update on Treatment of Drug-Induced Liver Injury." Journal of clinical and translational hepatology vol. 2,2 (2014): 74-9. doi: https://doi.org/10.14218/JCTH.2014.00005
Giordano C, Rivas J, Zervos X. An Update on Treatment of Drug-Induced Liver Injury. J Clin Transl Hepatol. 2014 Jun;2(2):74-9. doi: 10.14218/JCTH.2014.00005. Epub 2014 Jun 15. PMID: 26356645; PMCID: PMC4521262.
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J Clin Transl Hepatol. 2014 Jun;2(2):74-9. doi: 10.14218/JCTH.2014.00005. Epub 2014 Jun 15.

An Update on Treatment of Drug-Induced Liver Injury.

Journal of clinical and translational hepatology

Christin Giordano, John Rivas, Xaralambos Zervos

Affiliations

  1. Department of Faculty and Academic Affairs, University of Central Florida, College of Medicine, Orlando, FL, USA.
  2. Digestive Disease Institute, Cleveland Clinic Florida, Weston, FL, USA.

PMID: 26356645 PMCID: PMC4521262 DOI: 10.14218/JCTH.2014.00005

Abstract

Drug-induced liver injury (DILI) has been linked to more than 1,000 medications and remains the most common cause of acute liver failure in the United States. Here, we review the most current literature regarding treatment and make recommendations for the management of this relatively common disease. Since treatment of DILI remains largely elusive, recent studies have attempted to define new management strategies for these difficult patients. Early diagnosis and withdrawal of the suspected medication is the mainstay of treatment of DILI. For acetaminophen and Amanita mushroom poisoning, there are specific therapies in use. Finally, there are other possible management modalities for DILI, including corticosteroids and ursodeoxycholic acid.

Keywords: Acetaminophen toxicity; Drug-induced liver injury; Hepatotoxicity

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