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Bayraktar S, Qiu H, Liu D, et al. Histopathological Features of Non-Neoplastic Breast Parenchyma Do Not Predict BRCA Mutation Status of Patients with Invasive Breast Cancer. Biomark Cancer. 2015;7:39-49doi: 10.4137/BIC.S29716.
Bayraktar, S., Qiu, H., Liu, D., Shen, Y., Gutierrez-Barrera, A. M., Arun, B. K., & Sahin, A. A. (2015). Histopathological Features of Non-Neoplastic Breast Parenchyma Do Not Predict BRCA Mutation Status of Patients with Invasive Breast Cancer. Biomarkers in cancer, 739-49. https://doi.org/10.4137/BIC.S29716
Bayraktar, Soley, et al. "Histopathological Features of Non-Neoplastic Breast Parenchyma Do Not Predict BRCA Mutation Status of Patients with Invasive Breast Cancer." Biomarkers in cancer vol. 7 (2015): 39-49. doi: https://doi.org/10.4137/BIC.S29716
Bayraktar S, Qiu H, Liu D, Shen Y, Gutierrez-Barrera AM, Arun BK, Sahin AA. Histopathological Features of Non-Neoplastic Breast Parenchyma Do Not Predict BRCA Mutation Status of Patients with Invasive Breast Cancer. Biomark Cancer. 2015 Aug 18;7:39-49. doi: 10.4137/BIC.S29716. eCollection 2015. PMID: 26327783; PMCID: PMC4541461.
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Biomark Cancer. 2015 Aug 18;7:39-49. doi: 10.4137/BIC.S29716. eCollection 2015.

Histopathological Features of Non-Neoplastic Breast Parenchyma Do Not Predict BRCA Mutation Status of Patients with Invasive Breast Cancer.

Biomarkers in cancer

Soley Bayraktar, Hongming Qiu, Diane Liu, Yu Shen, Angelica M Gutierrez-Barrera, Banu K Arun, Aysegul A Sahin

Affiliations

  1. Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
  2. Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
  3. Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
  4. Department of Breast Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

PMID: 26327783 PMCID: PMC4541461 DOI: 10.4137/BIC.S29716

Abstract

BACKGROUND: Several studies have evaluated histologic features of non-neoplastic breast parenchyma in patients with BRCA1/2 mutations, but the results are conflicting. The limited data suggest a much higher prevalence of high-risk precursor lesions in BRCA carriers. Therefore, we designed this study to compare the clinicopathological characteristics of peritumoral benign breast tissue in patients with and without deleterious BRCA mutations.

METHODS: Women with breast cancer (BC) who were referred for genetic counseling and underwent BRCA genetic testing in 2010 and 2011 were included in the study.

RESULTS: Of the six benign histological features analyzed in this study, only stromal fibrosis grade 2/3 was found to be statistically different, with more BRCA noncarriers having stromal fibrosis grade 2/3 than BRCA1/2 carriers (P = 0.04).

CONCLUSION: There is no significant association between mutation risk and the presence of benign histologic features of peritumoral breast parenchyma.

Keywords: BRCA mutation; breast cancer; lobular sclerosis; lobular type; lobulitis; peritumoral breast parenchyma; stromal fibrosis

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