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Kim MJ, Kim TH, Lee HH. G-protein Coupled Estrogen Receptor (GPER/GPR30) and Women's Health. J Menopausal Med. 2015;21(2):79-81doi: 10.6118/jmm.2015.21.2.79.
Kim, M. J., Kim, T. H., & Lee, H. H. (2015). G-protein Coupled Estrogen Receptor (GPER/GPR30) and Women's Health. Journal of menopausal medicine, 21(2), 79-81. https://doi.org/10.6118/jmm.2015.21.2.79
Kim, Mi-Jin, et al. "G-protein Coupled Estrogen Receptor (GPER/GPR30) and Women's Health." Journal of menopausal medicine vol. 21,2 (2015): 79-81. doi: https://doi.org/10.6118/jmm.2015.21.2.79
Kim MJ, Kim TH, Lee HH. G-protein Coupled Estrogen Receptor (GPER/GPR30) and Women's Health. J Menopausal Med. 2015 Aug;21(2):79-81. doi: 10.6118/jmm.2015.21.2.79. Epub 2015 Aug 28. PMID: 26357644; PMCID: PMC4561744.
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J Menopausal Med. 2015 Aug;21(2):79-81. doi: 10.6118/jmm.2015.21.2.79. Epub 2015 Aug 28.

G-protein Coupled Estrogen Receptor (GPER/GPR30) and Women's Health.

Journal of menopausal medicine

Mi-Jin Kim, Tae-Hee Kim, Hae-Hyeog Lee

Affiliations

  1. Department of Obstetrics and Gynecology, Soonchunhyang University College of Medicine, Bucheon, Korea. ; Department of Interdisciplinary Program in Biomedical Science, Soonchunhyang University, Asan, Korea.
  2. Department of Obstetrics and Gynecology, Soonchunhyang University College of Medicine, Bucheon, Korea.

PMID: 26357644 PMCID: PMC4561744 DOI: 10.6118/jmm.2015.21.2.79

Abstract

Estrogen - the female sexual hormone playing the most important role - plays a physiologically significant role, not only regulating in cell signals with second messenger but also being active in regulating transcription. Estrogen receptor (ER) which is a protein accepting estrogen not only play the role of a transcription factor combining with other genes to regulate their activity like other nuclear receptors but also performs external activities, combining with DNA, etc. G-protein coupled ER (GPER) that has been recently discovered exists as 7-membrane and has non-genomic (rapid) signaling. These functions, however, are not extensively addressed. This paper discusses the roles of GPER and its physiological mechanism.

Keywords: Estradiol; Estrogens; GTP-binding proteins; Genomics

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