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Huang LH, Elvington A, Randolph GJ. The role of the lymphatic system in cholesterol transport. Front Pharmacol. 2015;6:182doi: 10.3389/fphar.2015.00182.
Huang, L. H., Elvington, A., & Randolph, G. J. (2015). The role of the lymphatic system in cholesterol transport. Frontiers in pharmacology, 6182. https://doi.org/10.3389/fphar.2015.00182
Huang, Li-Hao, et al. "The role of the lymphatic system in cholesterol transport." Frontiers in pharmacology vol. 6 (2015): 182. doi: https://doi.org/10.3389/fphar.2015.00182
Huang LH, Elvington A, Randolph GJ. The role of the lymphatic system in cholesterol transport. Front Pharmacol. 2015 Sep 02;6:182. doi: 10.3389/fphar.2015.00182. eCollection 2015. PMID: 26388772; PMCID: PMC4557107.
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Front Pharmacol. 2015 Sep 02;6:182. doi: 10.3389/fphar.2015.00182. eCollection 2015.

The role of the lymphatic system in cholesterol transport.

Frontiers in pharmacology

Li-Hao Huang, Andrew Elvington, Gwendalyn J Randolph

Affiliations

  1. Department of Pathology and Immunology, Washington University School of Medicine , St. Louis, MO, USA.

PMID: 26388772 PMCID: PMC4557107 DOI: 10.3389/fphar.2015.00182

Abstract

Reverse cholesterol transport (RCT) is the pathway for removal of peripheral tissue cholesterol and involves transport of cholesterol back to liver for excretion, starting from cellular cholesterol efflux facilitated by lipid-free apolipoprotein A1 (ApoA1) or other lipidated high-density lipoprotein (HDL) particles within the interstitial space. Extracellular cholesterol then is picked up and transported through the lymphatic vasculature before entering into bloodstream. There is increasing evidence supporting a role for enhanced macrophage cholesterol efflux and RCT in ameliorating atherosclerosis, and recent data suggest that these processes may serve as better diagnostic biomarkers than plasma HDL levels. Hence, it is important to better understand the processes governing ApoA1 and HDL influx into peripheral tissues from the bloodstream, modification and facilitation of cellular cholesterol removal within the interstitial space, and transport through the lymphatic vasculature. New findings will complement therapeutic strategies for the treatment of atherosclerotic vascular disease.

Keywords: apolipoprotein A1; atherosclerosis; cholesterol efflux; cholesterol reverse transport; high-density lipoprotein modification; high-density lipoprotein transport; interstitial space; lymphatics

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