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Ramchandra R, Barrett CJ. Regulation of the renal sympathetic nerves in heart failure. Front Physiol. 2015;6:238doi: 10.3389/fphys.2015.00238.
Ramchandra, R., & Barrett, C. J. (2015). Regulation of the renal sympathetic nerves in heart failure. Frontiers in physiology, 6238. https://doi.org/10.3389/fphys.2015.00238
Ramchandra, Rohit, and Barrett, Carolyn J. "Regulation of the renal sympathetic nerves in heart failure." Frontiers in physiology vol. 6 (2015): 238. doi: https://doi.org/10.3389/fphys.2015.00238
Ramchandra R, Barrett CJ. Regulation of the renal sympathetic nerves in heart failure. Front Physiol. 2015 Aug 25;6:238. doi: 10.3389/fphys.2015.00238. eCollection 2015. PMID: 26388778; PMCID: PMC4556040.
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Front Physiol. 2015 Aug 25;6:238. doi: 10.3389/fphys.2015.00238. eCollection 2015.

Regulation of the renal sympathetic nerves in heart failure.

Frontiers in physiology

Rohit Ramchandra, Carolyn J Barrett

Affiliations

  1. Department of Physiology, The University of Auckland Auckland, New Zealand.

PMID: 26388778 PMCID: PMC4556040 DOI: 10.3389/fphys.2015.00238

Abstract

Heart failure (HF) is a serious debilitating condition with poor survival rates and an increasing level of prevalence. HF is associated with an increase in renal norepinephrine (NE) spillover, which is an independent predictor of mortality in HF patients. The excessive sympatho-excitation that is a hallmark of HF has long-term effects that contribute to disease progression. An increase in directly recorded renal sympathetic nerve activity (RSNA) has also been recorded in animal models of HF. This review will focus on the mechanisms controlling sympathetic nerve activity (SNA) to the kidney during normal conditions and alterations in these mechanisms during HF. In particular the roles of afferent reflexes and central mechanisms will be discussed.

Keywords: central control; heart failure; renal sympathetic nerve activity

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