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Nikitidou O, Peppa VI, Leivaditis K, et al. Animal models in peritoneal dialysis. Front Physiol. 2015;6:244doi: 10.3389/fphys.2015.00244.
Nikitidou, O., Peppa, V. I., Leivaditis, K., Eleftheriadis, T., Zarogiannis, S. G., & Liakopoulos, V. (2015). Animal models in peritoneal dialysis. Frontiers in physiology, 6244. https://doi.org/10.3389/fphys.2015.00244
Nikitidou, Olga, et al. "Animal models in peritoneal dialysis." Frontiers in physiology vol. 6 (2015): 244. doi: https://doi.org/10.3389/fphys.2015.00244
Nikitidou O, Peppa VI, Leivaditis K, Eleftheriadis T, Zarogiannis SG, Liakopoulos V. Animal models in peritoneal dialysis. Front Physiol. 2015 Sep 01;6:244. doi: 10.3389/fphys.2015.00244. eCollection 2015. PMID: 26388781; PMCID: PMC4555018.
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Front Physiol. 2015 Sep 01;6:244. doi: 10.3389/fphys.2015.00244. eCollection 2015.

Animal models in peritoneal dialysis.

Frontiers in physiology

Olga Nikitidou, Vasiliki I Peppa, Konstantinos Leivaditis, Theodoros Eleftheriadis, Sotirios G Zarogiannis, Vassilios Liakopoulos

Affiliations

  1. Division of Nephrology and Hypertension, 1st Department of Internal Medicine, School of Medicine, American Hellenic Educational Progressive Association Hospital, Aristotle University of Thessaloniki Thessaloniki, Greece.
  2. Department of Physiology, Faculty of Medicine, BIOPOLIS, University of Thessaly Larissa, Greece.

PMID: 26388781 PMCID: PMC4555018 DOI: 10.3389/fphys.2015.00244

Abstract

Peritoneal dialysis (PD) has been extensively used over the past years as a method of kidney replacement therapy for patients with end stage renal disease (ESRD). In an attempt to better understand the properties of the peritoneal membrane and the mechanisms involved in major complications associated with PD, such as inflammation, peritonitis and peritoneal injury, both in vivo and ex vivo animal models have been used. The aim of the present review is to briefly describe the animal models that have been used, and comment on the main problems encountered while working with these models. Moreover, the differences characterizing these animal models, as well as, the differences with humans are highlighted. Finally, it is suggested that the use of standardized protocols is a necessity in order to take full advantage of animal models, extrapolate their results in humans, overcome the problems related to PD and help promote its use.

Keywords: animal models; ion and water transport; membrane physiology; peritoneal dialysis; ussing chamber

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