Front Physiol. 2015 Sep 03;6:248. doi: 10.3389/fphys.2015.00248. eCollection 2015.
Country of birth affects blood pressure in the French hypertensive diabetic population.
Frontiers in physiology
Sola Aoun Bahous, Frédérique Thomas, Bruno Pannier, Nicolas Danchin, Michel E Safar
Affiliations
Affiliations
- Lebanese American University Medical Center Beirut, Lebanon.
- Centre d'Investigations Préventives et Cliniques (IPC) Paris, France.
- Centre d'Investigations Préventives et Cliniques (IPC) Paris, France ; Institut National de la Santé et de la Recherche Médicale U 970, Hôpital Manhès Fleury-Mérogis, France.
- Centre d'Investigations Préventives et Cliniques (IPC) Paris, France ; Cardiology Department, Hôpital Européen Georges-Pompidou, Université Paris-Descartes Paris, France.
- AP-HP, Diagnostic and Therapeutic Center, Paris Descartes University Hôtel-Dieu, Paris, France.
PMID: 26388785
PMCID: PMC4558466 DOI: 10.3389/fphys.2015.00248
Abstract
In a population of 56,242 individuals living in France, we showed that individuals born in France have significantly different levels of blood pressure (BP) and cardiovascular (CV) risk factors than African and Asian populations born in their own country but living long-term in France (average duration of stay, 5-10 years). The objective of our study was to investigate the impact of country of birth on BP and CV risk factors in a subpopulation of 9245 patients selected solely on the diagnosis of hypertension, either alone or with simultaneous type 2 diabetes. In the subgroup of individuals with hypertension alone, brachial systolic, diastolic, mean and pulse pressure (PP), heart rate (HR), augmentation index and PP amplification were significantly higher in African-born than French- and Asian-born populations. In the subgroup of individuals with both hypertension and diabetes, only augmentation index, PP amplification and brachial and central PP, but not brachial systolic, diastolic, mean BP, and HR, were elevated when the African-born subgroup was compared to the French- and Asian-born populations. Increased body mass index (BMI), waist-hip ratio (WHR), and deprivation scores, but not increased plasma lipids or glycemia, were consistently associated with the African-born population. The combination of diabetes and hypertension in African populations was associated with increased aortic stiffness and PP, together with greater body weight and WHR. In individuals with increased PP and hence systolic hypertension, increased PP requires systolic BP to be reduced whereas notable reductions in diastolic BP may have deleterious consequences.
Keywords: aortic stiffness; country of birth; diabetes mellitus; ethnicity; hypertension; wave reflection
References
- Hypertension. 2011 Jun;57(6):1101-7 - PubMed
- J Am Coll Cardiol. 2012 May 15;59(20):1771-7 - PubMed
- J Am Soc Hypertens. 2009 May-Jun;3(3):166-83 - PubMed
- Can J Physiol Pharmacol. 2003 Mar;81(3):205-11 - PubMed
- Am J Hypertens. 2007 Jun;20(6):648-9 - PubMed
- Hypertension. 2000 Oct;36(4):594-9 - PubMed
- Circulation. 2008 Aug 26;118(9):968-76 - PubMed
- J Am Soc Hypertens. 2012 Nov-Dec;6(6):405-13 - PubMed
- Hypertension. 2007 Jul;50(1):172-80 - PubMed
- Hypertension. 2011 Jun;57(6):1108-16 - PubMed
- J Clin Hypertens (Greenwich). 2002 Nov-Dec;4(6):393-404 - PubMed
- J Am Soc Hypertens. 2013 Mar-Apr;7(2):163-9 - PubMed
- Hypertension. 2011 Oct;58(4):546-7 - PubMed
- Hypertension. 2013 May;61(5):943-7 - PubMed
- JAMA. 2010 May 26;303(20):2043-50 - PubMed
- Hypertension. 2002 Nov;40(5):640-6 - PubMed
- Physiology (Bethesda). 2007 Aug;22:252-60 - PubMed
- J Am Coll Cardiol. 1983 May;1(5):1348-51 - PubMed
- Hypertension. 2010 Apr;55(4):855-61 - PubMed
- J Am Coll Cardiol. 2013 Jan 8;61(1):12-9 - PubMed
- Hypertension. 1979 Mar-Apr;1(2):136-41 - PubMed
Publication Types