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Teven CM, Fisher S, Ameer GA, et al. Biomimetic approaches to complex craniofacial defects. Ann Maxillofac Surg. 2015;5(1):4-13doi: 10.4103/2231-0746.161044.
Teven, C. M., Fisher, S., Ameer, G. A., He, T. C., & Reid, R. R. (2015). Biomimetic approaches to complex craniofacial defects. Annals of maxillofacial surgery, 5(1), 4-13. https://doi.org/10.4103/2231-0746.161044
Teven, Chad M, et al. "Biomimetic approaches to complex craniofacial defects." Annals of maxillofacial surgery vol. 5,1 (2015): 4-13. doi: https://doi.org/10.4103/2231-0746.161044
Teven CM, Fisher S, Ameer GA, He TC, Reid RR. Biomimetic approaches to complex craniofacial defects. Ann Maxillofac Surg. 2015 Jan-Jun;5(1):4-13. doi: 10.4103/2231-0746.161044. PMID: 26389027; PMCID: PMC4555947.
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Ann Maxillofac Surg. 2015 Jan-Jun;5(1):4-13. doi: 10.4103/2231-0746.161044.

Biomimetic approaches to complex craniofacial defects.

Annals of maxillofacial surgery

Chad M Teven, Sean Fisher, Guillermo A Ameer, Tong-Chuan He, Russell R Reid

Affiliations

  1. Department of Surgery, Section of Plastic and Reconstructive Surgery, University of Chicago Medical Center, Chicago, IL, USA.
  2. Department of Biomedical Engineering, Northwestern University, Evanston, IL, USA.
  3. Department of Orthopedic Surgery, University of Chicago Medical Center, Chicago, IL, USA.

PMID: 26389027 PMCID: PMC4555947 DOI: 10.4103/2231-0746.161044

Abstract

The primary goals of craniofacial reconstruction include the restoration of the form, function, and facial esthetics, and in the case of pediatric patients, respect for craniofacial growth. The surgeon, however, faces several challenges when attempting a reconstructive cranioplasty. For that reason, craniofacial defect repair often requires sophisticated treatment strategies and multidisciplinary input. In the ideal situation, autologous tissue similar in structure and function to that which is missing can be utilized for repair. In the context of the craniofacial skeleton, autologous cranial bone, or secondarily rib, iliac crest, or scapular bone, is most favorable. Often, this option is limited by the finite supply of available bone. Therefore, alternative strategies to repair craniofacial defects are necessary. In the field of regenerative medicine, tissue engineering has emerged as a promising concept, and several methods of bone engineering are currently under investigation. A growth factor-based approach utilizing bone morphogenetic proteins (BMPs) has demonstrated stimulatory effects on cranial bone and defect repair. When combined with cell-based and matrix-based models, regenerative goals can be optimized. This manuscript intends to review recent investigations of tissue engineering models used for the repair of craniofacial defects with a focus on the role of BMPs, scaffold materials, and novel cell lines. When sufficient autologous bone is not available, safe and effective strategies to engineer bone would allow the surgeon to meet the reconstructive goals of the craniofacial skeleton.

Keywords: Biomimetic; bone morphogenetic protein; craniofacial defect repair; scaffold matrix; three-dimensional scaffold

References

  1. Proc Natl Acad Sci U S A. 2003 Oct 14;100(21):12277-82 - PubMed
  2. Bone. 2009 Jul;45(1):4-16 - PubMed
  3. Stem Cells. 2013 Sep;31(9):1840-56 - PubMed
  4. Oncogene. 2002 Oct 17;21(47):7156-63 - PubMed
  5. J Biomed Mater Res A. 2014 Dec;102(12):4317-25 - PubMed
  6. Plast Reconstr Surg. 2009 Jan;123(1):319-30 - PubMed
  7. ANZ J Surg. 2007 Aug;77(8):626-31 - PubMed
  8. Acta Biomater. 2011 Nov;7(11):4057-63 - PubMed
  9. J Bone Joint Surg Am. 2001;83-A Suppl 1(Pt 1):S56-62 - PubMed
  10. Cell. 2003 Jun 13;113(6):685-700 - PubMed
  11. Proc Natl Acad Sci U S A. 2014 Apr 8;111(14):E1354-63 - PubMed
  12. Biomaterials. 2005 Oct;26(30):5983-90 - PubMed
  13. Science. 1965 Nov 12;150(3698):893-9 - PubMed
  14. J Clin Invest. 2005 Sep;115(9):2373-81 - PubMed
  15. J Tissue Eng Regen Med. 2016 Oct;10 (10 ):E337-E353 - PubMed
  16. J Biomed Mater Res B Appl Biomater. 2015 Jul;103(5):971-82 - PubMed
  17. Biomaterials. 2006 Dec;27(34):5845-54 - PubMed
  18. Plast Reconstr Surg. 2013 Oct;132(4):967-75 - PubMed
  19. Nature. 1997 Dec 4;390(6659):465-71 - PubMed
  20. J Biomed Mater Res A. 2010 Jun 15;93(4):1358-67 - PubMed
  21. Adv Drug Deliv Rev. 2003 Nov 28;55(12):1613-29 - PubMed
  22. Tissue Eng. 2007 Mar;13(3):619-27 - PubMed
  23. Ann Maxillofac Surg. 2014 Jan;4(1):4-8 - PubMed
  24. J Dent Res. 2014 Dec;93(12):1187-95 - PubMed
  25. J Biochem. 2012 Mar;151(3):247-54 - PubMed
  26. Int J Biol Sci. 2009;5(2):192-200 - PubMed
  27. J Craniofac Surg. 2015 Jun;26(4):1207-13 - PubMed
  28. PLoS Med. 2007 Feb;4(2):e9 - PubMed
  29. Biomaterials. 2006 Mar;27(8):1399-409 - PubMed
  30. Int J Mol Sci. 2014 Feb 28;15(3):3640-59 - PubMed
  31. Cancer Res. 2007 Sep 1;67(17):8149-55 - PubMed
  32. Biomaterials. 2006 Oct;27(28):4894-903 - PubMed
  33. Cytokine Growth Factor Rev. 1998 Mar;9(1):49-61 - PubMed
  34. Biomed Mater. 2014 Apr;9(2):025003 - PubMed
  35. Plast Reconstr Surg. 2005 May;115(6):1642-50 - PubMed
  36. J Craniofac Surg. 2012 Mar;23(2):586-93 - PubMed
  37. J Craniofac Surg. 2009 Jan;20(1):29-33 - PubMed
  38. Science. 1988 Dec 16;242(4885):1528-34 - PubMed
  39. Ann Biomed Eng. 2004 Mar;32(3):477-86 - PubMed
  40. Bone. 2005 Oct;37(4):563-9 - PubMed
  41. J Biochem. 2010 Jan;147(1):35-51 - PubMed
  42. J Biomed Biotechnol. 2012;2012:601549 - PubMed
  43. Biointerphases. 2014 Jun;9(2):029011 - PubMed
  44. J Surg Tech Case Rep. 2011 Jan;3(1):13-6 - PubMed
  45. Biochem Biophys Res Commun. 2003 Jan 31;301(1):84-91 - PubMed
  46. Biotechnol Lett. 2009 Dec;31(12):1817-24 - PubMed
  47. PLoS One. 2012;7(2):e32428 - PubMed
  48. Osteoarthritis Cartilage. 2006 Nov;14(11):1126-35 - PubMed
  49. Eur Cell Mater. 2010 Oct 04;20:218-30 - PubMed
  50. Ann Plast Surg. 2016 May;76(5):509-16 - PubMed
  51. Dev Biol. 2004 Dec 1;276(1):158-71 - PubMed
  52. Plast Reconstr Surg. 1991 Jul;88(1):31-8 - PubMed
  53. Biotechnol Lett. 2004 Jul;26(13):1037-41 - PubMed
  54. Genes Dev. 1995 Nov 15;9(22):2808-20 - PubMed
  55. Biomaterials. 1994 Oct;15(13):1075-81 - PubMed
  56. J Biomed Mater Res A. 2014 Feb;102(2):366-72 - PubMed
  57. Biomaterials. 2005 Jun;26(18):3919-28 - PubMed
  58. Proc Natl Acad Sci U S A. 2010 Dec 28;107(52):22425-9 - PubMed
  59. N Engl J Med. 2000 May 4;342(18):1350-8 - PubMed
  60. Biotechnol Lett. 2009 Dec;31(12):1825-35 - PubMed
  61. J Plast Reconstr Aesthet Surg. 2010 Oct;63(10):1615-23 - PubMed
  62. J Biomed Mater Res. 2002;63(3):271-9 - PubMed
  63. Development. 1996 Oct;122(10):2977-86 - PubMed
  64. Cell Signal. 2011 Apr;23(4):609-20 - PubMed
  65. Trends Biotechnol. 2012 Oct;30(10):546-54 - PubMed
  66. PLoS One. 2010 Jun 17;5(6):e11177 - PubMed
  67. Curr Gene Ther. 2005 Apr;5(2):167-79 - PubMed
  68. Science. 2002 Feb 8;295(5557):1009-14 - PubMed
  69. Open Bone J. 2012;4:null - PubMed
  70. Dev Genet. 1998;22(4):321-39 - PubMed
  71. Nat Genet. 2001 Oct;29(2):117-29 - PubMed
  72. Stem Cells Dev. 2009 May;18(4):545-59 - PubMed
  73. Gene Ther. 2004 Sep;11(17):1312-20 - PubMed
  74. Plast Reconstr Surg. 2006 Sep 15;118(4):862-73 - PubMed
  75. Craniomaxillofac Trauma Reconstr. 2008 Nov;1(1):49-61 - PubMed
  76. Plast Reconstr Surg. 1998 Mar;101(3):567-74; discussion 575-6 - PubMed
  77. Tissue Eng Part A. 2009 Sep;15(9):2571-9 - PubMed
  78. Dev Biol. 1999 Apr 1;208(1):222-32 - PubMed
  79. Appl Biochem Biotechnol. 2014 Mar;172(6):3016-25 - PubMed
  80. Development. 1996 Nov;122(11):3587-95 - PubMed
  81. Hum Mutat. 2008 Aug;29(8):1017-27 - PubMed
  82. Tissue Eng. 2003;9 Suppl 1:S127-39 - PubMed
  83. Nat Genet. 2001 Jan;27(1):84-8 - PubMed
  84. Biomaterials. 2006 Jun;27(18):3413-31 - PubMed
  85. Genes Dev. 1995 Sep 1;9(17):2105-16 - PubMed
  86. J Mech Behav Biomed Mater. 2014 Nov;39:218-30 - PubMed
  87. J Craniofac Surg. 1999 Sep;10 (5):404-14 - PubMed
  88. Genesis. 2003 Jan;35(1):43-56 - PubMed
  89. Tissue Eng Part A. 2012 May;18(9-10):1006-13 - PubMed
  90. J Biomed Mater Res B Appl Biomater. 2015 Feb;103(2):243-53 - PubMed
  91. Craniomaxillofac Trauma Reconstr. 2009 Oct;2(3):125-34 - PubMed
  92. Science. 1996 Jan 19;271(5247):360-2 - PubMed
  93. Curr Gene Ther. 2001 Jul;1(2):149-62 - PubMed
  94. Dev Biol. 1994 Nov;166(1):112-22 - PubMed
  95. Hum Gene Ther. 2003 Apr 10;14(6):591-7 - PubMed
  96. J Orthop Res. 2007 May;25(5):665-77 - PubMed
  97. Plast Reconstr Surg. 2006 Oct;118(5):122e-133e - PubMed
  98. Curr Gene Ther. 2011 Jun;11(3):229-40 - PubMed
  99. J Bone Joint Surg Am. 2001;83-A Suppl 1(Pt 1):S23-30 - PubMed
  100. Acta Biomater. 2014 Nov;10(11):4597-605 - PubMed
  101. Int Orthop. 2007 Dec;31(6):721-7 - PubMed
  102. Am J Med Genet A. 2011 Jul;155A(7):1646-53 - PubMed
  103. PLoS One. 2007 Feb 07;2(2):e190 - PubMed
  104. J Bone Joint Surg Am. 2001;83-A Suppl 1(Pt 1):S48-55 - PubMed
  105. J Musculoskelet Neuronal Interact. 2005 Oct-Dec;5(4):363-6 - PubMed
  106. Biochim Biophys Acta. 1997 Oct 24;1333(2):F105-50 - PubMed
  107. J Biomed Mater Res. 1994 Dec;28(12):1445-53 - PubMed

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