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Koscianska E, Krzyzosiak WJ. Current understanding of the role of microRNAs in spinocerebellar ataxias. Cerebellum Ataxias. 2014;1:7doi: 10.1186/2053-8871-1-7.
Koscianska, E., & Krzyzosiak, W. J. (2014). Current understanding of the role of microRNAs in spinocerebellar ataxias. Cerebellum & ataxias, 17. https://doi.org/10.1186/2053-8871-1-7
Koscianska, Edyta, and Krzyzosiak, Wlodzimierz J. "Current understanding of the role of microRNAs in spinocerebellar ataxias." Cerebellum & ataxias vol. 1 (2014): 7. doi: https://doi.org/10.1186/2053-8871-1-7
Koscianska E, Krzyzosiak WJ. Current understanding of the role of microRNAs in spinocerebellar ataxias. Cerebellum Ataxias. 2014 Aug 07;1:7. doi: 10.1186/2053-8871-1-7. eCollection 2014. PMID: 26331031; PMCID: PMC4552431.
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Cerebellum Ataxias. 2014 Aug 07;1:7. doi: 10.1186/2053-8871-1-7. eCollection 2014.

Current understanding of the role of microRNAs in spinocerebellar ataxias.

Cerebellum & ataxias

Edyta Koscianska, Wlodzimierz J Krzyzosiak

Affiliations

  1. Department of Molecular Biomedicine, Institute of Bioorganic Chemistry, Polish Academy of Sciences, Noskowskiego 12/14 Str, 61-704 Poznan, Poland.

PMID: 26331031 PMCID: PMC4552431 DOI: 10.1186/2053-8871-1-7

Abstract

The number of studies highlighting the role of microRNAs (miRNAs) in human physiology and diseases is growing, but many miRNA-driven regulatory mechanisms remain elusive. A proper understanding of the exact functions of individual miRNAs and their interaction with specific targets is vitally important because such knowledge might help cure diseases for which no effective treatment currently exists. Herein, we present current views on the role of the miRNA-mediated regulation of gene expression in the case of select spinocerebellar ataxias (SCAs) and their potential involvement in the pathogenesis of these diseases. Specifically, we summarize published data showing the known links between miRNAs and CAG repeat-dependent SCAs. Moreover, using the example of SCA type 3 (SCA3), we refer to the issue of prediction and validation of miRNA targets, and we demonstrate that miR-181a-1 may regulate the 3'-UTR of the ATXN3 gene.

Keywords: Ataxin; Luciferase assay; PolyQ expansion; TREDs; Target validation; miRNA

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