Display options
Cite
Choi WY, Kim HE, Moon YW, et al. Production of porous Calcium Phosphate (CaP) ceramics with aligned pores using ceramic/camphene-based co-extrusion. Biomater Res. 2015;19:16doi: 10.1186/s40824-015-0037-z.
Choi, W. Y., Kim, H. E., Moon, Y. W., Shin, K. H., & Koh, Y. H. (2015). Production of porous Calcium Phosphate (CaP) ceramics with aligned pores using ceramic/camphene-based co-extrusion. Biomaterials research, 1916. https://doi.org/10.1186/s40824-015-0037-z
Choi, Won-Young, et al. "Production of porous Calcium Phosphate (CaP) ceramics with aligned pores using ceramic/camphene-based co-extrusion." Biomaterials research vol. 19 (2015): 16. doi: https://doi.org/10.1186/s40824-015-0037-z
Choi WY, Kim HE, Moon YW, Shin KH, Koh YH. Production of porous Calcium Phosphate (CaP) ceramics with aligned pores using ceramic/camphene-based co-extrusion. Biomater Res. 2015 Jul 03;19:16. doi: 10.1186/s40824-015-0037-z. eCollection 2015. PMID: 26331085; PMCID: PMC4552288.
Copy Download .nbib Format: NLM
Share it on

Biomater Res. 2015 Jul 03;19:16. doi: 10.1186/s40824-015-0037-z. eCollection 2015.

Production of porous Calcium Phosphate (CaP) ceramics with aligned pores using ceramic/camphene-based co-extrusion.

Biomaterials research

Won-Young Choi, Hyoun-Ee Kim, Young-Wook Moon, Kwan-Ha Shin, Young-Hag Koh

Affiliations

  1. Department of Materials Science and Engineering, Seoul National University, Seoul, 151-742 Korea.
  2. School of Biomedical Engineering, Korea University, Seoul, 136-703 Korea.

PMID: 26331085 PMCID: PMC4552288 DOI: 10.1186/s40824-015-0037-z

Abstract

BACKGROUND: Calcium phosphate (CaP) ceramics are one of the most valuable biomaterials for uses as the bone scaffold owing to their outstanding biocompatability, bioactivity, and biodegradation nature. In particular, these materials with an open porous structure can stimulate bone ingrowth into their 3-dimensionally interconnected pores. However, the creation of pores in bulk materials would inevitably cause a severe reduction in mechanical properties. Thus, it is a challenge to explore new ways of improving the mechanical properties of porous CaP scaffolds without scarifying their high porosity.

RESULTS: Porous CaP ceramic scaffolds with aligned pores were successfully produced using ceramic/camphene-based co-extrusion. This aligned porous structure allowed for the achievement of high compressive strength when tested parallel to the direction of aligned pores. In addition, the overall porosity and mechanical properties of the aligned porous CaP ceramic scaffolds could be tailored simply by adjusting the initial CaP content in the CaP/camphene slurry. The porous CaP scaffolds showed excellent in vitro biocompatibility, suggesting their potential as the bone scaffold.

CONCLUSIONS: Aligned porous CaP ceramic scaffolds with considerably enhanced mechanical properties and tailorable porosity would find very useful applications as the bone scaffold.

Keywords: Bone regeneration; Calcium phosphate; Pores; Porous materials; Scaffold

References

  1. Biomaterials. 2010 Mar;31(7):1465-85 - PubMed
  2. Science. 2006 Jan 27;311(5760):479-80 - PubMed
  3. J Funct Biomater. 2010 Nov 30;1(1):22-107 - PubMed
  4. J Biomech. 2005 Mar;38(3):377-99 - PubMed
  5. Acta Biomater. 2012 Mar;8(3):963-77 - PubMed
  6. J Mater Sci Mater Med. 2008 Jul;19(7):2743-9 - PubMed
  7. Science. 2006 Jan 27;311(5760):515-8 - PubMed
  8. J Biomed Mater Res B Appl Biomater. 2008 Jul;86(1):125-35 - PubMed
  9. Acta Biomater. 2010 Mar;6(3):876-85 - PubMed
  10. Biomaterials. 2006 Nov;27(32):5480-9 - PubMed
  11. Tissue Eng Part B Rev. 2013 Dec;19(6):485-502 - PubMed

Publication Types