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Xu T, Alper H. Synthesis of Indolizine Derivatives by Pd-Catalyzed Oxidative Carbonylation. Org Lett. 2015;17(18):4526-9doi: 10.1021/acs.orglett.5b02220.
Xu, T., & Alper, H. (2015). Synthesis of Indolizine Derivatives by Pd-Catalyzed Oxidative Carbonylation. Organic letters, 17(18), 4526-9. https://doi.org/10.1021/acs.orglett.5b02220
Xu, Tongyu, and Alper, Howard. "Synthesis of Indolizine Derivatives by Pd-Catalyzed Oxidative Carbonylation." Organic letters vol. 17,18 (2015): 4526-9. doi: https://doi.org/10.1021/acs.orglett.5b02220
Xu T, Alper H. Synthesis of Indolizine Derivatives by Pd-Catalyzed Oxidative Carbonylation. Org Lett. 2015 Sep 18;17(18):4526-9. doi: 10.1021/acs.orglett.5b02220. Epub 2015 Sep 02. PMID: 26331787.
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Org Lett. 2015 Sep 18;17(18):4526-9. doi: 10.1021/acs.orglett.5b02220. Epub 2015 Sep 02.

Synthesis of Indolizine Derivatives by Pd-Catalyzed Oxidative Carbonylation.

Organic letters

Tongyu Xu, Howard Alper

Affiliations

  1. Centre for Catalysis Research and Innovation, Department of Chemistry and Biomolecular Sciences, University of Ottawa , 10 Marie Curie, Ottawa, Ontario, Canada , K1N 6N5.

PMID: 26331787 DOI: 10.1021/acs.orglett.5b02220

Abstract

An efficient synthesis of indolizine derivatives by palladium-catalyzed oxidative carbonylation of propargylic pyridines has been developed. The reaction can be conducted at room temperature and under 3 bar of CO in the presence of Pd2(dba)3 or Pd/C. The catalyst Pd/C could be easily removed from the reaction and recycled.

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