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Curr Chem Biol. 2014 Aug;8(2):89-102. doi: 10.2174/2212796809666150227223857.

Using Copper to Improve the Well-Being of the Skin.

Current chemical biology

Gadi Borkow

Affiliations

  1. Cupron Inc. Hasadnaot 10, Herzelia, Israel.

PMID: 26361585 PMCID: PMC4556990 DOI: 10.2174/2212796809666150227223857

Abstract

Copper has two key properties that are being exploited in consumer and medical device products in the last decade. On the one hand, copper has potent biocidal properties. On the other hand, copper is involved in numerous physiological and metabolic processes critical for the appropriate functioning of almost all tissues in the human body. In the skin, copper is involved in the synthesis and stabilization of extracellular matrix skin proteins and angiogenesis. This manuscript reviews clinical studies that show that the use of textile consumer and medical device products, embedded with microscopic copper oxide particles, improve the well-being of the skin. These include studies showing a) cure of athlete's foot infections and improvement in skin elasticity, especially important for individuals suffering from diabetes; b) reduction of facial fine line and wrinkles; and c) enhancement of wound healing; by copper oxide embedded socks, pillowcases and wound dressings, respectively. The manuscript also reviews and discusses the mechanisms by which the presence of copper in these products improves skin well-being.

Keywords: Biocide; copper; extracellular matrix; skin; textiles; wound healing.

References

  1. Langmuir. 2013 Dec 31;29(52):16160-6 - PubMed
  2. Eur J Dermatol. 2002 Jul-Aug;12(4):390-9; quiz 400-1 - PubMed
  3. Med Hypotheses. 2008;70(3):610-3 - PubMed
  4. Appl Environ Microbiol. 2008 Feb;74(4):977-86 - PubMed
  5. BMC Microbiol. 2014 Mar 07;14:57 - PubMed
  6. Biopolymers. 1976 Oct;15(10):1879-1902 - PubMed
  7. Appl Environ Microbiol. 2011 Mar;77(5):1541-7 - PubMed
  8. Arch Dermatol Res. 2007 Oct;299(8):373-9 - PubMed
  9. Mol Cell Biochem. 1999 Apr;194(1-2):257-63 - PubMed
  10. Am J Clin Nutr. 1998 May;67(5 Suppl):965S-971S - PubMed
  11. Contraception. 2008 May;77(5):318-27 - PubMed
  12. Arch Dermatol Res. 2009 Apr;301(4):301-6 - PubMed
  13. Wound Repair Regen. 2010 Mar-Apr;18(2):266-75 - PubMed
  14. Acta Biomater. 2009 Feb;5(2):541-53 - PubMed
  15. Antimicrob Agents Chemother. 2008 Feb;52(2):518-25 - PubMed
  16. Proc Natl Acad Sci U S A. 1991 Jul 1;88(13):5552-6 - PubMed
  17. Med Hypotheses. 2009 Dec;73(6):883-6 - PubMed
  18. J Cosmet Dermatol. 2012 Sep;11(3):193-200 - PubMed
  19. Chem Biol Interact. 1976 Aug;14(3-4):347-56 - PubMed
  20. Contact Dermatitis. 2014 Oct;71(4):191-201 - PubMed
  21. Antimicrob Agents Chemother. 2007 Jul;51(7):2605-7 - PubMed
  22. J Nutr. 1999 Jul;129(7):1251-60 - PubMed
  23. Best Pract Res Clin Obstet Gynaecol. 2002 Apr;16(2):155-68 - PubMed
  24. Int J Mol Med. 2001 Jan;7(1):3-12 - PubMed
  25. Commun Agric Appl Biol Sci. 2008;73(2):169-78 - PubMed
  26. Int J Cosmet Sci. 2009 Dec;31(6):437-43 - PubMed
  27. J Natl Cancer Inst. 1982 Nov;69(5):1183-8 - PubMed
  28. Am J Clin Nutr. 1998 May;67(5 Suppl):952S-959S - PubMed
  29. Int J Infect Dis. 2014 Jul;24:23-9 - PubMed
  30. Infect Control Hosp Epidemiol. 1995 Aug;16(8):444-50 - PubMed
  31. Int J Cosmet Sci. 2012 Oct;34(5):416-23 - PubMed
  32. Wound Repair Regen. 2007 Sep-Oct;15(5):636-45 - PubMed
  33. Foot (Edinb). 2008 Sep;18(3):136-41 - PubMed
  34. Biochemistry. 1983 Dec 20;22(26):6156-63 - PubMed
  35. Ageing Res Rev. 2015 May;21:16-29 - PubMed
  36. Rev Environ Health. 2003 Jul-Sep;18(3):153-83 - PubMed
  37. Am J Clin Nutr. 1998 May;67(5 Suppl):996S-1002S - PubMed
  38. Am J Physiol Heart Circ Physiol. 2002 May;282(5):H1821-7 - PubMed
  39. Med Hypotheses. 2008;70(5):990-4 - PubMed
  40. Biometals. 2014 Dec;27(6):1179-89 - PubMed
  41. Cold Spring Harb Perspect Med. 2015 Jan 05;5(1):a015370 - PubMed
  42. Int J Biochem. 1987;19(12):1141-7 - PubMed
  43. J Cosmet Sci. 2010 Mar-Apr;61(2):125-32 - PubMed
  44. Arch Dermatol Res. 2009 Aug;301(7):487-95 - PubMed
  45. Nurs Stand. 2012 Sep 19-25;27(3):35-42 - PubMed
  46. Pest Manag Sci. 2007 Aug;63(8):784-8 - PubMed
  47. J Cell Biochem. 1998 Jun 1;69(3):326-35 - PubMed
  48. Chem Rev. 2014 Apr 9;114(7):3854-918 - PubMed
  49. J Mater Sci Mater Med. 2008 Sep;19(9):3057-62 - PubMed
  50. Int J Burns Trauma. 2012;2(1):18-28 - PubMed
  51. Am J Ther. 2004 Nov-Dec;11(6):453-8 - PubMed
  52. J Biomater Sci Polym Ed. 2008;19(8):969-88 - PubMed
  53. Int J Cosmet Sci. 2008 Oct;30(5):313-22 - PubMed
  54. Connect Tissue Res. 2012;53(5):373-8 - PubMed
  55. Curr Med Chem. 2005;12(18):2163-75 - PubMed
  56. J Biol Chem. 2008 Dec 5;283(49):34229-40 - PubMed
  57. Arch Dermatol Res. 2010 Mar;302(2):71-83 - PubMed
  58. Pathol Biol (Paris). 2005 Sep;53(7):448-56 - PubMed
  59. Proc Natl Acad Sci U S A. 2012 Aug 14;109(33):13243-7 - PubMed
  60. Wounds. 2010 Dec;22(12):301-10 - PubMed
  61. Arch Dermatol. 2008 May;144(5):666-72 - PubMed
  62. Arch Biochem Biophys. 2000 Oct 1;382(1):72-80 - PubMed
  63. Skin Res Technol. 2015 Aug;21(3):272-7 - PubMed
  64. J Invest Dermatol. 1999 May;112(5):782-7 - PubMed
  65. Eur J Contracept Reprod Health Care. 2008 Mar;13(1):9-16 - PubMed
  66. Skin Pharmacol Physiol. 2009;22(3):151-7 - PubMed
  67. FASEB J. 2004 Nov;18(14):1728-30 - PubMed
  68. Int J Low Extrem Wounds. 2007 Jun;6(2):82-97 - PubMed
  69. J Bacteriol. 1988 Jun;170(6):2676-82 - PubMed
  70. Microbiology. 2013 Jun;159(Pt 6):1190-7 - PubMed
  71. Pigment Cell Melanoma Res. 2009 Dec;22(6):750-60 - PubMed
  72. Toxicol Appl Pharmacol. 1991 Sep 15;110(3):477-85 - PubMed
  73. J Am Diet Assoc. 2001 Mar;101(3):294-301 - PubMed
  74. PLoS One. 2010 Jun 25;5(6):e11295 - PubMed
  75. Food Chem Toxicol. 2006 Sep;44(9):1539-43 - PubMed
  76. Connect Tissue Res. 2010 Jun;51(3):224-9 - PubMed
  77. Acta Derm Venereol. 1993 Feb;73(1):41-5 - PubMed
  78. Am J Pathol. 2009 Jan;174(1):101-14 - PubMed
  79. Microbiologyopen. 2012 Mar;1(1):46-52 - PubMed

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